Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.2

Reaction

5,6-dihydrouracil
+
NADP+
=
Uracil
+
NADPH
+
H+

Synonyms

4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00018
-
at 30°C
0.00173
-
crude enzyme, at pH 7.4 and 25°C
0.0043
-
mutant C671A
0.118
-
cell line CAL 27
0.122
-
cell line CAL 7
0.184
-
cell line CAL 33
0.265
-
cell line PANC 3
0.318
-
cell line CAL 51
0.35
-
-
0.38
-
purified enzyme
0.417 - 0.5
-
purified enzyme
0.43
-
-
0.705
-
after 407.5fold purification, at pH 7.4 and 25°C
14
-
recombinant from Escherichia coli
182.1
-
purified enzyme
2.2
-
substrate hydrothymine
20.9
-
substrate 5-iodouracil
21
-
purified enzyme
21.5
-
substrate 5-diazouracil
27.9
-
substrate thymine
34.9
-
substrate uracil
4.7
-
substrate nitouracil
46.9
-
substrate 5-bromouracil
47.4
-
substrate 5-fluorouracil
additional information