1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
This is an abbreviated version!
For detailed information about trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, go to the full flat file.
Word Map on EC 1.3.1.20
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1.3.1.20
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dihydrodiol
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trans-dihydrodiols
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medicine
-
polycyclic
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catechols
-
nadp+-dependent
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benzenedihydrodiol
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indomethacin
-
penning
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alpha-hydroxysteroids
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o-quinones
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talalay
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anti-diol
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1.1.1.184
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+/-trans-7,8-dihydroxy-7,8-dihydrobenzoapyrene
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non-k-region
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benzaanthracene
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alicyclic
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trans-1,2-dihydrodiols
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dicoumarol
-
chrysene
-
benzoapyrene-7,8-dione
-
harvey
-
pah-induced
-
androsterone
-
diagnostics
- 1.3.1.20
- dihydrodiol
-
trans-dihydrodiols
- medicine
-
polycyclic
- catechols
-
nadp+-dependent
- benzenedihydrodiol
- indomethacin
-
penning
-
alpha-hydroxysteroids
- o-quinones
-
talalay
-
anti-diol
-
1.1.1.184
-
+/-trans-7,8-dihydroxy-7,8-dihydrobenzoapyrene
-
non-k-region
-
benzaanthracene
-
alicyclic
-
trans-1,2-dihydrodiols
- dicoumarol
- chrysene
-
benzoapyrene-7,8-dione
-
harvey
-
pah-induced
- androsterone
- diagnostics
Reaction
Synonyms
AKR1C1, AKR1C2, DD, DDH, DDH1, DDH2, dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol, DHDH, dihydrodiol dehydrogenase, More
ECTree
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenaseAdvanced search results
results (
results (Results
in table
12
187
76
130
61
95
19
24
64
IC50 Value
IC50 Value on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.00097
4-hydroxyacetophenone
Macaca fuscata
-
wild type enzyme, in 25 mM Tris-HCl pH 7.5, at 25°C
0.00097
4-hydroxyacetophenone
Macaca fascicularis
determined in the camphorquinone reduction, inhibitor is uncompetitive with respect to camphorquinone
0.00097
4-hydroxyacetophenone
Macaca fascicularis
the hydroxyl group of 4-hydroxyacetophenone forms hydrogen bond interactions with the side-chain oxygen and the main chain nitrogen of Asp280, the benzene ring and methyl group make a number of hydrophobic contacts with Phe279, Leu158 and Leu177
0.006
4-hydroxyacetophenone
Macaca fuscata
-
mutant enzyme W254Y, in 25 mM Tris-HCl pH 7.5, at 25°C
0.075
4-hydroxyacetophenone
Macaca fuscata
-
mutant enzyme F154A, in 25 mM Tris-HCl pH 7.5, at 25°C
0.078
4-hydroxyacetophenone
Macaca fuscata
-
mutant enzyme F154A, in 25 mM Tris-HCl pH 7.5, at 25°C
0.083
4-hydroxyacetophenone
Macaca fuscata
-
mutant enzyme W254A, in 25 mM Tris-HCl pH 7.5, at 25°C
0.136
4-hydroxyacetophenone
Macaca fuscata
-
mutant enzyme W125Y, in 25 mM Tris-HCl pH 7.5, at 25°C
0.038
isoascorbic acid
Macaca fuscata
-
mutant enzyme W254Y, in 25 mM Tris-HCl pH 7.5, at 25°C
0.038
isoascorbic acid
Macaca fascicularis
determined in the camphorquinone reduction, inhibitor is uncompetitive with respect to camphorquinone
0.066
isoascorbic acid
Macaca fuscata
-
mutant enzyme W254A, in 25 mM Tris-HCl pH 7.5, at 25°C
0.288
isoascorbic acid
Macaca fuscata
-
mutant enzyme F154A, in 25 mM Tris-HCl pH 7.5, at 25°C
3.94
isoascorbic acid
Macaca fuscata
-
mutant enzyme F154A, in 25 mM Tris-HCl pH 7.5, at 25°C
4.176
isoascorbic acid
Macaca fuscata
-
mutant enzyme W125Y, in 25 mM Tris-HCl pH 7.5, at 25°C
