1.3.1.21: 7-dehydrocholesterol reductase
This is an abbreviated version!
For detailed information about 7-dehydrocholesterol reductase, go to the full flat file.
Word Map on EC 1.3.1.21
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1.3.1.21
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smith-lemli-opitz
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malformation
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cyp2r1
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anomaly
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25-hydroxyvitamin
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syndactyly
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d-related
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desmosterol
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8-dehydrocholesterol
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dhcr24
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genitalia
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oxysterols
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holoprosencephaly
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rsh
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ecdysteroids
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cholesterogenic
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medicine
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diagnostics
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25-hydroxylase
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trazodone
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aripiprazole
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ebp
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hmgcs1
- 1.3.1.21
-
smith-lemli-opitz
- malformation
- cyp2r1
- anomaly
-
25-hydroxyvitamin
-
syndactyly
-
d-related
- desmosterol
- 8-dehydrocholesterol
- dhcr24
-
genitalia
- oxysterols
- holoprosencephaly
- rsh
- ecdysteroids
-
cholesterogenic
- medicine
- diagnostics
-
25-hydroxylase
- trazodone
- aripiprazole
- ebp
- hmgcs1
Reaction
Synonyms
3-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol-DELTA7-reductase, 7-dehydrocholesterol DELTA7 reductase, 7-dehydrocholesterol DELTA7-reductase, 7-DHC reductase, 7-DHCR, Csa7G447780, DAF-36, DELTA5,7-sterol DELTA7-reductase, Des7, Dhcr7, Dhcr7-AS-1, Dhcr7-AS-2, Dhcr7-AS-4, Dwarf5 protein, DWF5, Neverland, Nvd, reductase, 7-dehydrocholesterol, Sterol delta-7-reductase, sterol DELTA7 reductase, sterol DELTA7-reductase
ECTree
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Inhibitors
Inhibitors on EC 1.3.1.21 - 7-dehydrocholesterol reductase
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1-[p-(beta-Diethylaminoethoxy) phenyl]1-(p-tolyl)-2-(p-chlorophenyl)ethanol
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i.e. MER-29 or triparanol
2-[2-(4-chlorophenyl)ethyl]-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline
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strong and selective inhibition of 7-dehydrocholesterol reductase, stronger inhibition of overall cholesterol biosynthesis than BM 15.766, presently the most selective known inhibitor of 7-DHCR
20S-hydroxy-7-dehydrocholesterol
inhibits the conversion of ergosterol to brassicasterol similarly to 7-dehydrocholesterol
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27-hydroxydehydrocholesterol
inhibits the conversion of ergosterol by 25%
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4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid
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i.e. BM 15.766 non-competitive
7-dehydrocholesterol
0.03 mM, inhibits the conversion of ergosterol to brassicasterol by 93%
AY9944
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i.e. AY9944, competitive inhibitor of DHCR7 enzyme activity and inductor of DHCR7 expression. It blocks hedgehog signaling upstream of the Gli transcription factors, overview
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treatment of adult human epidermal keratinocytes with 0.01 mM cyclopamine results in a decrease in enzyme activity (50% of control activity at 3 h)
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i.e. AY-9944, hypercholesterolaemic drug
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
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i.e. AY-9944, hypercholesterolaemic drug
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
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i.e. AY-9944, hypercholesterolaemic drug; non-competitive
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feed-back inhibition through 3-hydroxy-3-methylglutaryl-CoA reductase
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additional information
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feed-back inhibition through 3-hydroxy-3-methylglutaryl-CoA reductase
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additional information
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in enzyme deficiency, accumulated 7-dehydrocholesterol suppresses sterol biosynthesis in vivo
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additional information
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not inhibited by 1alpha,25-dihydroxyvitamin D3 and vitamin D3
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additional information
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analysis of physiological effects of immunoneutralization of the enzyme in Leydig cells
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additional information
not inhibitory: 7-dehydropregnenolone, 25(OH)7-dehydrocholesterol, L3 or vitamin D3
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