1.3.1.21: 7-dehydrocholesterol reductase

This is an abbreviated version!
For detailed information about 7-dehydrocholesterol reductase, go to the full flat file.

Word Map on EC 1.3.1.21

1.3.1.21

smith-lemli-opitz

malformation

cyp2r1

anomaly

25-hydroxyvitamin

syndactyly

d-related

desmosterol

8-dehydrocholesterol

dhcr24

genitalia

oxysterols

holoprosencephaly

rsh

ecdysteroids

cholesterogenic

medicine

diagnostics

25-hydroxylase

trazodone

aripiprazole

ebp

hmgcs1

Reaction

cholesterol

+

NADP⁺

=

cholesta-5,7-dien-3beta-ol

+

NADPH

+

H+

Synonyms

3-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol DELTA7-reductase, 3beta-hydroxysterol-DELTA7-reductase, 7-dehydrocholesterol DELTA7 reductase, 7-dehydrocholesterol DELTA7-reductase, 7-DHC reductase, 7-DHCR, Csa7G447780, DAF-36, DELTA5,7-sterol DELTA7-reductase, Des7, Dhcr7, Dhcr7-AS-1, Dhcr7-AS-2, Dhcr7-AS-4, Dwarf5 protein, DWF5, Neverland, Nvd, reductase, 7-dehydrocholesterol, Sterol delta-7-reductase, sterol DELTA7 reductase, sterol DELTA7-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.21 7-dehydrocholesterol reductase

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Results	in table
6	Activating Compound
80	AA Sequence
13	Application
1	CAS Registry Number
22	Cloned(Commentary)
35	Cofactor
550	Disease/ Diagnostics
1	Expression
19	General Information
3	General Stability
7	IC50 Value
113	Inhibitors
7	Ki Value [mM]
4	KM Value [mM]
33	Localization
1	Metals/Ions
5	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
209	Organism
13	Pathway
5	pH Optimum
2	Posttranslational Modification
63	Protein Variants
2	Purification (Commentary)
4	Reaction
3	Reaction Type
70	Reference
75	Source Tissue
7	Specific Activity [micromol/min/mg]
123	Substrates and Products (Substrate)
7	Subunits
57	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 1.3.1.21 - 7-dehydrocholesterol reductase

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(+)-pachysamine B

-

-

1,4-bis-[2-chlorobenzylaminomethyl]-cyclohexane

-

AY-9944

1-[3-(2,4,6-trimethoxybenzoyl)propyl]-pyrrolidinium chloride

-

-

1-[p-(beta-Diethylaminoethoxy) phenyl]1-(p-tolyl)-2-(p-chlorophenyl)ethanol

Rattus norvegicus

-

i.e. MER-29 or triparanol

349269, 349270, 349274

2-[2-(4-chlorophenyl)ethyl]-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

-

strong and selective inhibition of 7-dehydrocholesterol reductase, stronger inhibition of overall cholesterol biosynthesis than BM 15.766, presently the most selective known inhibitor of 7-DHCR

20,25-Diazacholesterol

Rattus norvegicus

-

-

20S-hydroxy-7-dehydrocholesterol

Rattus norvegicus

inhibits the conversion of ergosterol to brassicasterol similarly to 7-dehydrocholesterol

-

20S-hydroxylumisterol

Rattus norvegicus

-

-

22-hydroxy-lumisterol

Rattus norvegicus

-

-

25-hydroxyvitamin D3

-

-

27-hydroxydehydrocholesterol

Rattus norvegicus

inhibits the conversion of ergosterol by 25%

-

3'-methoxy-4'-hydroxyclomiphene

-

-

3beta-[2-(diethylamino)ethoxy]androst-5-en-17-one

Rattus norvegicus

-

i.e. U18666A

4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid

show

6,7-diaza-5alpha-cholest-8(14)-en-3beta-ol

-

-

6,7-diaza-5beta-cholest-8(14)-en-3beta-ol

-

-

6-aza-B-homo-5alpha-cholest-7-en-3beta-ol

-

-

6-aza-B-homo-5alpha-cholest-8-en-3beta-ol

-

-

7-dehydrocholesterol

show

8-dehydrocholesterol

Rattus norvegicus

-

8beta-cyano-6,7-diaza-5alpha-cholest-5-en-3beta-ol

-

-

acebutolol

-

-

afimoxifene

-

-

altanserin

-

-

aripiprazole

-

-

AY9944

show

BM 15.766

-

-

BM15.766

show

brassicasterol

Rattus norvegicus

-

higher concentration, competitive

buspirone

-

-

captopril

-

-

CGS 12066B

-

-

Chloropromazine

-

-

cholest-5,7-dien-3beta-ol

-

-

cisapride

-

-

clobenpropit

-

-

clozapine

-

-

cyclopamine

show

dofetilide

-

-

donepezil

-

-

doxorubicin

-

-

droperidol

-

-

E-4031

-

-

EDTA

-

-

epicholesterol

Rattus norvegicus

-

higher concentration, competitive

epipachysamine D

-

-

ergosterol

Rattus norvegicus

-

non-competetively, concentration 0.025 mM

esmolol

-

-

fluoxetine

-

-

formoterol

-

-

haloperidol

show

ifenprodil

-

-

isoxsuprine

-

-

lobeline

-

-

lofexidine

-

-

loxoprofen

-

-

LY-117018

-

-

monomethylarsonous acid

-

-

N-(3-trifluoromethylphenyl)piperazine

-

-

N-nitrosodimethylamine

-

-

nafadotride

-

-

nafoxidine

-

-

naftopidil

-

-

nefazodone

-

-

ochratoxin A

-

-

oxybutynin

-

-

pergolide

-

-

perospirone

-

-

pirenperone

-

-

potassium dichromate

-

-

proadifen

-

-

procaine

-

-

progesterone

-

-

rel-ormeloxifene

-

-

risperidone

-

-

salmeterol

-

-

simvastatin

-

-

sitosterol

Rattus norvegicus

-

higher concentration, competitive

tamoxifen

-

-

tesmilifene

-

-

trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride

show

trazodone

-

-

trioxifene

-

-

Triparanol

Rattus norvegicus

-

-

vesamicol

-

-

additional information

show

-

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Release 2023.1 (January 2023)