1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase

This is an abbreviated version!
For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file.

Word Map on EC 1.3.1.3

Reaction

17,21-dihydroxy-5beta-pregnane-3,11,20-trione
+
NADP+
=
cortisone
+
NADPH
+
H+

Synonyms

3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, aldo-keto reductase, aldo-keto reductase 1D1, aldo–keto reductase 1D1, androstenedione 5beta-reductase, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase

Inhibitors

Inhibitors on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17beta-hydroxy-5alpha-androstan-3-one
-
0.01 mM, 57% inhibition
17beta-hydroxy-5beta-androstan-3-one
-
0.01 mM, 28% inhibition
4-benzoylbenzoic acid
-
-
5beta-dihydrotestosterone
-
product inhibition
androstenedione
chenodeoxycholic acid
Cu2+
-
0.5 mM 66% inhibition
estradiol-17beta
-
0.01 mM, 29% inhibition
estrone
-
0.01 mM, 29% inhibition
Hg2+
-
0.1 mM, 92% inhibition
indomethacin
-
-
iodoacetate
-
-
Mefenamic acid
-
-
N-ethylmaleimide
-
-
NADP+
-
product inhibition
p-chloromercuribenzenesulfonate
-
-
p-chloromercuribenzoate
p-Chloromercuribenzyl sulfonate
-
2 mM, complete inhibition, 50% inhibition in the presence of 10 mM glutathione
progesterone
testosterone
Ursodeoxycholic acid
-
-
additional information
-