1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase

This is an abbreviated version!
For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file.

Word Map on EC 1.3.1.3

1.3.1.3

bile

chenodeoxycholic

digitalis

akr1c4

cardenolide

lanata

bile-acids

cyp7b1

delta4-3-ketosteroids

tocolytic

srd5a1

pre-receptor

medicine

Reaction

17,21-dihydroxy-5beta-pregnane-3,11,20-trione

Synonyms

3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, AKR1D4, aldo-keto reductase, aldo-keto reductase 1D1, aldo�keto reductase 1D1, androstenedione 5beta-reductase, CARUB_v10005016mg, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.23, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, SRD5beta, St5betaR1, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase

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Results	in table
37	AA Sequence
5	Application
2	CAS Registry Number
20	Cloned(Commentary)
27	Cofactor
9	Crystallization (Commentary)
96	Disease/ Diagnostics
6	Expression
11	General Information
4	General Stability
30	Inhibitors
43	kcat/KM [mM/s]
5	Ki Value [mM]
78	KM Value [mM]
9	Localization
7	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
45	Organism
6	Pathway
34	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
49	Protein Variants
18	Purification (Commentary)
6	Reaction
6	Reaction Type
43	Reference
29	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
123	Substrates and Products (Substrate)
7	Subunits
67	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
53	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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17beta-hydroxy-5alpha-androstan-3-one

Pelophylax lessonae

0.01 mM, 57% inhibition

390649

17beta-hydroxy-5beta-androstan-3-one

Pelophylax lessonae

0.01 mM, 28% inhibition

390649

4-benzoylbenzoic acid

Homo sapiens

726492

5beta-dihydrotestosterone

Sus scrofa

product inhibition

390596

androstenedione

2 entries

chenodeoxycholic acid

2 entries

Cu2+

Pelophylax lessonae

0.5 mM 66% inhibition

390649

estradiol-17beta

Pelophylax lessonae

0.01 mM, 29% inhibition

390649

estrone

Pelophylax lessonae

0.01 mM, 29% inhibition

390649

Hg2+

Pelophylax lessonae

0.1 mM, 92% inhibition

indomethacin

iodoacetate

Mefenamic acid

N-ethylmaleimide

NADP+

product inhibition

p-chloromercuribenzenesulfonate

Sus scrofa

390596

p-chloromercuribenzoate

3 entries

p-Chloromercuribenzyl sulfonate

Rattus norvegicus

2 mM, complete inhibition, 50% inhibition in the presence of 10 mM glutathione

progesterone

testosterone

Ursodeoxycholic acid

additional information

3 entries