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0.0032
1,4-androstadien-17beta-ol-3-one
-
pH 6.0, 37°C
0.116 - 1.15
2-cyclohexen-1-one
0.0009 - 2.193
4-androstene-3,17-dione
0.0008
4-cholesten-7alpha-ol-3-one
-
pH 6.0, 37°C
0.003
4-estren-17beta-ol-3-one
-
pH 6.0, 37°C
0.0122
7alpha,12alpha-dihydroxy-4-cholesten-3-one
-
-
0.0091
7alpha-hydroxy-4-cholesten-3-one
-
-
0.0025
aldosterone
-
pH 6.0, 37°C
0.022
androst-4-en-3,17-dione
-
-
0.0022
androst-4-ene-3,17-dione
-
-
0.00037 - 0.01629
androstenedione
0.0003
cholestenone
-
pH 6.0, 37°C
0.0022
corticosterone
-
pH 6.0, 37°C
0.0029
Epitestosterone
-
pH 6.0, 37°C
0.00219 - 0.362
progesterone
0.0016 - 0.0127
testosterone
additional information
additional information
-
0.116
2-cyclohexen-1-one
pH 8.0, 40°C, recombinant wild-type enzyme
0.175
2-cyclohexen-1-one
-
pH 8.0, 40°C, recombinant mutant N205A
0.196
2-cyclohexen-1-one
-
pH 8.0, 40°C, recombinant mutant N205M
0.333
2-cyclohexen-1-one
-
pH 8.0, 40°C, recombinant wild-type enzyme
0.334
2-cyclohexen-1-one
-
pH 8.0, 40°C, recombinant mutant Y156V/N205M
0.358
2-cyclohexen-1-one
mutant R63K/R64H, cofactor NADPH, pH 6, 40°C
0.443
2-cyclohexen-1-one
wild-type, cofactor NADPH, pH 6, 40°C
0.541
2-cyclohexen-1-one
mutant R63K/R64H, cofactor NADH, pH 6, 40°C
1.15
2-cyclohexen-1-one
-
pH 8.0, 40°C, recombinant mutant Y156V
0.0009
4-androstene-3,17-dione
-
pH 6.0, 37°C
0.0022
4-androstene-3,17-dione
-
-
0.00485
4-androstene-3,17-dione
-
-
0.0057
4-androstene-3,17-dione
isoform AKR1D4L, pH 7, 37°C
0.008
4-androstene-3,17-dione
isoform AKR1D4S, pH 7, 37°C
0.228
4-androstene-3,17-dione
-
2.193
4-androstene-3,17-dione
-
0.00037
androstenedione
pH 7.4, 37°C, wild-type enzyme
0.00094
androstenedione
pH 7.4, 37°C, mutant Y132F
0.01629
androstenedione
pH 7.4, 37°C, mutant V309F
1.597
cortexone
-
0.0071
cortisol
isoform AKR1D4L, pH 7, 37°C
0.0114
cortisol
isoform AKR1D4S, pH 7, 37°C
0.0131
cortisol
-
pH 6.0, 37°C
0.0013
cortisone
mutant P133R, pH not specified in the publication, temperature not specified in the publication
0.0013
cortisone
pH 6.0, 37°C, mutant P133R
0.0151
cortisone
-
pH 6.0, 37°C
0.0151
cortisone
pH 6.0, 37°C, wild-type enzyme
0.0151
cortisone
wild-type, pH not specified in the publication, temperature not specified in the publication
0.003
NADPH
-
-
0.00219
progesterone
-
-
0.0063
progesterone
-
wild-type, pH 7.4, 37°C
0.0105
progesterone
-
mutant Y132G, pH 7.4, 37°C
0.063
progesterone
-
pH 8.0, 40°C, recombinant mutant N205M
0.072
progesterone
-
pH 8.0, 40°C, recombinant mutant Y156V
0.085
progesterone
-
pH 8.0, 40°C, recombinant mutant N205A
0.09
progesterone
-
pH 8.0, 40°C, recombinant mutant Y156V/N205M
0.12
progesterone
purified wild type enzyme
0.268
progesterone
pH 8.0, 40°C, recombinant wild-type enzyme
0.362
progesterone
-
pH 8.0, 40°C, recombinant wild-type enzyme
0.0016
testosterone
-
-
0.0027
testosterone
-
pH 6.0, 37°C
0.0027
testosterone
pH 6.0, 37°C, wild-type enzyme
0.0027
testosterone
-
in 100 mM potassium phosphate buffer (pH 6.0), at 37°C
0.0027
testosterone
wild-type, pH not specified in the publication, temperature not specified in the publication
0.0127
testosterone
mutant P133R, pH not specified in the publication, temperature not specified in the publication
0.0127
testosterone
pH 6.0, 37°C, mutant P133R
additional information
additional information
Michaelis-Menten kinetics for the reduction of androstenedione, overview
-
additional information
additional information
-
Michaelis-Menten kinetics for the reduction of androstenedione, overview
-
additional information
additional information
-
Henri-Michaelis-Menten steady-state kinetics of mutant enzyme P133R
-
additional information
additional information
Henri-Michaelis-Menten steady-state kinetics of mutant enzyme P133R
-