1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase

This is an abbreviated version!
For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file.

Word Map on EC 1.3.1.3

Reaction

17,21-dihydroxy-5beta-pregnane-3,11,20-trione
+
NADP+
=
cortisone
+
NADPH
+
H+

Synonyms

3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, aldo-keto reductase, aldo-keto reductase 1D1, aldo–keto reductase 1D1, androstenedione 5beta-reductase, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase

Natural Substrates Products

Natural Substrates Products on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
17alpha-hydroxyprogesterone + NADPH
?
show the reaction diagram
-
-
-
-
?
2-cyclohexen-1-one + NADPH + H+
cyclohexanone + NADP+
show the reaction diagram
4-androstene-3,17-dione + NADPH
5beta-androstan-3,17-dione + NADP+
show the reaction diagram
aldosterone + NADPH
?
show the reaction diagram
-
low activity
-
-
?
cholest-4-en-3-one + NADPH + H+
5beta-cholestan-3-one + NADP+
show the reaction diagram
-
-
-
?
corticosterone + NADPH
?
show the reaction diagram
-
low activity
-
-
?
cortisol + NADPH
?
show the reaction diagram
-
very low activity
-
-
?
cortisone + NADPH + H+
11beta,21dihydroxy-pregnan-3,11,20-trione + NADP+
show the reaction diagram
-
-
-
?
cortisone + NADPH + H+
17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+
show the reaction diagram
-
-
-
?
DELTA 4-cholestene-7alpha,12alpha-diol-3-one + NADPH + H+
5beta-cholestane-7alpha,12alpha-diol-3-one + NADP+
show the reaction diagram
-
a bile acid intermediate
-
-
?
DELTA4-cholesten-7alpha-ol-3-one + NADPH + H+
5beta-cholestan-7alpha-ol-3-one + NADP+
show the reaction diagram
-
a bile acid intermediate
-
-
?
progesterone + NADPH
?
show the reaction diagram
-
-
-
-
?
progesterone + NADPH + H+
5beta-pregnane-3,20-dione + NADP+
show the reaction diagram
progesterone + NADPH + H+
?
show the reaction diagram
-
-
-
?
testosterone + NADPH
?
show the reaction diagram
-
-
-
?
testosterone + NADPH + H+
(5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
show the reaction diagram
additional information
?
-