1.3.1.38: trans-2-enoyl-CoA reductase (NADPH)
This is an abbreviated version!
For detailed information about trans-2-enoyl-CoA reductase (NADPH), go to the full flat file.
Word Map on EC 1.3.1.38
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1.3.1.38
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beta-ketoacyl-coa
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beta-hydroxyacyl-coa
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dehydrase
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palmitoyl-coa
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butyryl-coa
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condensing
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vlcfas
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nadph-specific
- 1.3.1.38
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beta-ketoacyl-coa
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beta-hydroxyacyl-coa
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dehydrase
- palmitoyl-coa
- butyryl-coa
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condensing
-
vlcfas
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nadph-specific
Reaction
Synonyms
2-trans enoyl-ACP(CoA) reductase, ECR, EgTER1, enoyl reductase, InhA, MECR, MECR-1, mitochondrial 2-trans-enoyl-CoA/ACP reductase, mitochondrial 2-trans-enoyl-thioester reductase, NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, TER, trans-2-enoyl-CoA reductase, trans-2-enoyl-CoA reductase (NADPH)
ECTree
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Engineering
Engineering on EC 1.3.1.38 - trans-2-enoyl-CoA reductase (NADPH)
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G225A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
G234A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
I231A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
P232A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
P182L
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the mutant exhibits lower trans-2-enoyl-CoA reductase activity as compared with the wild type enzyme
F149A
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the mutant is not able to optimally position the cofactor for hydride transfer, which correlates with the 30fold decrease in kcat
additional information
knockdown of MECR-1 resulted in life span extension
additional information
knockdown of MECR-1 resulted in life span extension
additional information
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knockdown of MECR-1 resulted in life span extension
additional information
enzyme is able to rescue the growth of the Saccharomyces cerevisiae tsc13DELTA mutant
additional information
enzyme is able to rescue the growth of the Saccharomyces cerevisiae tsc13DELTA mutant
additional information
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enzyme is able to rescue the growth of the Saccharomyces cerevisiae tsc13DELTA mutant