1.3.1.54: precorrin-6A reductase

This is an abbreviated version!
For detailed information about precorrin-6A reductase, go to the full flat file.

Reaction

Synonyms

precorrin 6-X reductase, precorrin-6 reductase, precorrin-6A reductase, precorrin-6x reductase, precorrin-6Y:NADP+ oxidoreductase, Reductase, precorrin 6x (Pseudomonas denitrificans clone pXL367 gene cobK)

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.54 precorrin-6A reductase

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Results	in table
2805	AA Sequence
2	CAS Registry Number
2	Cloned(Commentary)
3	Cofactor
2	KM Value [mM]
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
9	Organism
5	Pathway
3	PDB ID
1	pH Optimum
20	Protein Variants
2	Purification (Commentary)
3	Reaction
6	Reaction Type
8	Reference
1	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
2	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Reference on EC 1.3.1.54 - precorrin-6A reductase

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3209

Roessner, C.A.; Spencer, J.B.; Ozaki, S.; Min, C.; Atshaves, B.P.; Nayar, P.; Anousis, N.; Stolowich, N.J.; Holderman, M.T.; Scott, A.I.

Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes

Protein Expr. Purif.

155-163

1995

Pseudomonas denitrificans (nom. rej.)

7606163

12308

Blanche, F.; Thibaut, D.; Famechon, A.; Debussche, L.; Cameron, B.; Crouzet, J.

Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene

J. Bacteriol.

174

1036-1042

1992

Pseudomonas denitrificans (nom. rej.)

1732193

655826

Shearer, N.; Hinsley, A.P.; Van Spanning, R.J.; Spiro, S.

Anaerobic growth of Paracoccus denitrificans requires cobalamin: characterization of cobK and cobJ genes

J. Bacteriol.

181

6907-6913

1999

Paracoccus denitrificans (Q9R9K2), Paracoccus denitrificans, Paracoccus denitrificans Pd 1222 (Q9R9K2)

10559155

656354

Kiuchi, F.; Thibaut, D.; Debussche, L.; Leeper, F.; Blanche, F.; Battersby, A.R.

Biosynthesis of vitamin B12: stereochemistry of transfer of a hydride equivalent from NADPH by precorrin-6x reductase

J. Chem. Soc.

Chem. Commun.

306-308

1992

Pseudomonas denitrificans (nom. rej.), Pseudomonas denitrificans (nom. rej.) SC510 Rif

671664

Kim, W.; Major, T.A.; Whitman, W.B.

Role of the precorrin 6-X reductase gene in cobamide biosynthesis in Methanococcus maripaludis

Archaea

375-384

2005

Methanococcus maripaludis (Q977V1), Methanococcus maripaludis, Methanococcus maripaludis JJ (Q977V1)

16243778