1.3.1.6: fumarate reductase (NADH)

This is an abbreviated version!
For detailed information about fumarate reductase (NADH), go to the full flat file.

Word Map on EC 1.3.1.6

Reaction

succinate
+
NAD+
=
fumarate
+
NADH
+
H+

Synonyms

FRD, FRdABCD, FRDg, FRDm1, FRDm2, FRDS, Frds1p, fumarate reductase, mitochondrial rhodoquinol-fumarate reductase, NADH-dependent fumarate reductase, NADH-FR, NADH-FRD, NADH-fumarate reductase, NFRD, QFR

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.6 fumarate reductase (NADH)

Inhibitors

Inhibitors on EC 1.3.1.6 - fumarate reductase (NADH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-5-ol
-
-
2',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
-
2,4-dimethoxy-4'-allyloxychalcone
2,4-dimethoxy-4'-butoxychalcone
2-n-heptyl-4-hydroxyquinoline-N-oxide
3',4',6-trihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
-
3',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
-
4',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
-
4,6,3'-hydroxy-4'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
-
4,6,4'-hydroxy-3'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
-
4,6,4'-triacetyl-3',5'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
i.e. bracteintriacetate
4,6-dihydroxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol
-
-
6-benzoyl-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol
-
-
6-hydroxy-2-[(2,3,4-trihydroxyphenyl)-methylene]-3(2H)-benzofuran-3-one-5-beta-D-glucopyranoside
-
i.e. bractein
6-hydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
-
6-hydroxy-3',4'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
-
6-hydroxy-benzofuran-3-one
-
-
6-methoxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
-
Acriflavin
-
specific inhibition of NADH dependent activity
Cinnamic acid
-
preincubation
citraconate
ClHgSO3H
-
inhibition with all cofactors except the methyl viologen dependent activity
decursin
-
-
decursinol
-
-
decursinol angelate
-
-
flutolanil
-
fungizide
iodoacetate
-
slight inhibition
KCN
-
inhibition with all cofactors except the methyl viologen dependent activity
licochalcone A
lipochalcone A
malonate
mesaconic acid
-
strong inhibition with and without preincubation
N-(4-[[2-(4-tert-butylphenyl)ethyl]amino]phthalazin-6-yl)prop-2-enamide
-
-
N-[2-(4-tert-butylphenyl)ethyl]-5-(1-methylethoxy)phthalazin-1-amine
-
-
N-[2-(4-tert-butylphenyl)ethyl]-5-methoxyphthalazin-1-amine
-
-
N-[2-(4-tert-butylphenyl)ethyl]phthalazin-1-amine
-
quinazoline
N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,6-diamine
-
-
N1-[2-(4-tert-butylphenyl)ethyl]phthalazine-1,7-diamine
-
-
p-chloromercuribenzoate
-
slight inhibition
Pd(2-mercaptopyridine N-oxide)2
-
Pd-(pyridine-2-thiol N-oxide)2
-
inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, marked increase is obeserved in the inhibitory effect with respect to that of the free ligand, inhibition in a dose-dependent manner, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate
Pt(2-mercaptopyridine N-oxide)2
-
Pt-(pyridine-2-thiol N-oxide)2
-
inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, inhibition observed 2 is similar to that obtained with the ligand alone, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate
pyridine-2-thiol N-oxide
-
2-mercaptopyridine N-oxide (mpo) is a bioactive ligand with a potential as antitrypanosomal agent
pyrvinium pamoate
sodium pyridine-2-thiol N-oxide
-
inhibitory effect of the sodium salt
succinate
trans-, trans muconate
-
slight inhibition
Triton X-100
-
complete loss of NADH dependent activity at concentration of 0.05%, up to 17fold increase in methyl viologen dependent activity
ukulactone A
ukulactone B
ukulactone C
-
-
VO(2-mercaptopyridine N-oxide)2
-
wortmannilactone E
-
-
wortmannilactone F
-
-
wortmannilactone H
-
-
wortmannilactone I
-
-
wortmannilactone J
-
-
wortmannilactone K
-
-
wortmannilactone L
-
-
additional information
-