1.3.1.6: fumarate reductase (NADH)

This is an abbreviated version!
For detailed information about fumarate reductase (NADH), go to the full flat file.

Word Map on EC 1.3.1.6

Reaction

succinate
+
NAD+
=
fumarate
+
NADH
+
H+

Synonyms

FRD, FRdABCD, FRDg, FRDm1, FRDm2, FRDS, Frds1p, fumarate reductase, mitochondrial rhodoquinol-fumarate reductase, NADH-dependent fumarate reductase, NADH-FR, NADH-FRD, NADH-fumarate reductase, NFRD, QFR

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.6 fumarate reductase (NADH)

Reference

Reference on EC 1.3.1.6 - fumarate reductase (NADH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hopgood, M.F.; Walker, D.J.
Succinic acid production by rumen bacteria: III Enzymatic studies on the formation of succinate by Ruminococcus flavefaciens
Aust. J. Biol. Sci.
22
1413-1424
1969
Ruminococcus flavefaciens
Manually annotated by BRENDA team
Aue, B.J.; Deibel, R.H.
Fumarate reductase activity of Streptococcus faecalis
J. Bacteriol.
93
1770-1776
1967
Enterococcus faecalis
Manually annotated by BRENDA team
Dorn, M.; Andreesen, J.R.; Gottschalk, G.
Fumarate reductase of Clostridium formicoaceticum. A peripheral membrane protein
Arch. Microbiol.
119
7-11
1978
Clostridium formicaceticum
Manually annotated by BRENDA team
Hillier, A.J.; Jericho, R.E.; Green, S.M.; Jago, G.R.
Properties and function of fumarate reductase (NADH) in Streptococcus lactis
Aust. J. Biol. Sci.
32
625-635
1979
Enterococcus faecalis, Lactococcus lactis
Manually annotated by BRENDA team
Wetzstein, H.G.; Gottschalk, G.
A sodium-stimulated membrane-bound fumarate reductase system in Bacteroides amylophilus
Arch. Microbiol.
143
157-162
1985
Ruminobacter amylophilus
Manually annotated by BRENDA team
Meinhardt, S.W.; Glass, T.L.
Characterization of the NADH dehydrogenase and fumarate reductase of Fibrobacter succinogenes subsp. succinogenes S85
Arch. Microbiol.
162
329-334
1994
Fibrobacter succinogenes
-
Manually annotated by BRENDA team
Christmas, P.B.; Turrens, J.F.
Separation of NADH-fumarate reductase and succinate dehydrogenase activities in Trypanosoma cruzi
FEMS Microbiol. Lett.
183
225-228
2000
Trypanosoma cruzi
Manually annotated by BRENDA team
Chen, M.; Zhai, L.; Christensen, S.B.; Theander, T.G.; Kharazmi, A.
Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones
Antimicrob. Agents Chemother.
45
2023-2029
2001
Leishmania donovani, Leishmania major
Manually annotated by BRENDA team
Chen, M.; Bennedsen, M.; Zhai, L.; Kharazmi, A.
Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites
APMIS
109
801-808
2001
Leishmania donovani, Leishmania major
Manually annotated by BRENDA team
Besteiro, S.; Biran, M.; Biteau, N.; Coustou, V.; Baltz, T.; Canioni, P.; Bringaud, F.
Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme: NADH-dependent fumarate reductase
J. Biol. Chem.
22
38001-38012
2002
Trypanosoma brucei (Q8ITL2)
-
Manually annotated by BRENDA team
Pankhurst, K.L.; Mowat, C.G.; Miles, C.S.; Leys, D.; Walkinshaw, M.D.; Reid, G.A.; Chapman, S.K.
Role of His505 in the soluble fumarate reductase from Shewanella frigidimarina
Biochemistry
41
8551-8556
2002
Shewanella frigidimarina
Manually annotated by BRENDA team
Rothery, E.L.; Mowat, C.G.; Miles, C.S.; Walkinshaw, M.D.; Reid, G.A.; Chapman, S.K.
Histidine 61: an important heme ligand in the soluble fumarate reductase from Shewanella frigidimarina
Biochemistry
42
13160-13169
2003
Shewanella frigidimarina
Manually annotated by BRENDA team
Denicola, A.; Rubbo, H.; Haden, L.; Turrens, J.F.
Extramitochondrial localization of NADH-fumarate reductase in trypanosomatids
Comp. Biochem. Physiol. B
133
23-27
2002
Leishmania donovani, Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani S-2
Manually annotated by BRENDA team
Enomoto, K.; Arikawa, Y.; Muratsubaki, H.
Physiological role of soluble fumarate reductase in redox balancing during anaerobiosis in Saccharomyces cerevisiae
FEMS Microbiol. Lett.
215
103-108
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Coustou, V.; Besteiro, S.; Riviere, L.; Biran, M.; Biteau, N.; Franconi, J.M.; Boshart, M.; Baltz, T.; Bringaud, F.
A mitochondrial NADH-dependent fumarate reductase involved in the production of succinate excreted by procyclic Trypanosoma brucei
J. Biol. Chem.
280
16559-16570
2005
Trypanosoma brucei (Q5BU12), Trypanosoma brucei (Q5BU14), Trypanosoma brucei (Q8ITL2), Trypanosoma brucei
Manually annotated by BRENDA team
Baughn, A.D.; Malamy, M.H.
The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis
Microbiology
149
1551-1558
2003
Bacteroides fragilis (Q7X478), Bacteroides fragilis (Q7X479), Bacteroides fragilis (Q7X480), Bacteroides fragilis
Manually annotated by BRENDA team
Kayser, O.; Chen, M.; Kharazmi, A.; Kiderlen, A.F.
Aurones interfere with Leishmania major mitochondrial fumarate reductase
Z. Naturforsch. C
57c
717-720
2002
Leishmania major
-
Manually annotated by BRENDA team
Hudson, J.M.; Heffron, K.; Kotlyar, V.; Sher, Y.; Maklashina, E.; Cecchini, G.; Armstrong, F.A.
Electron transfer and catalytic control by the iron-sulfur clusters in a respiratory enzyme, E. coli fumarate reductase
J. Am. Chem. Soc.
127
6977-6989
2005
Escherichia coli
Manually annotated by BRENDA team
Zaunmueller, T.; Kelly, D.J.; Gloeckner, F.O.; Unden, G.
Succinate dehydrogenase functioning by a reverse redox loop mechanism and fumarate reductase in sulphate-reducing bacteria
Microbiology
152
2443-2453
2006
Desulfovibrio desulfuricans
Manually annotated by BRENDA team
Matsumoto, J.; Sakamoto, K.; Shinjyo, N.; Kido, Y.; Yamamoto, N.; Yagi, K.; Miyoshi, H.; Nonaka, N.; Katakura, K.; Kita, K.; Oku, Y.
Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis
Antimicrob. Agents Chemother.
52
164-170
2008
Echinococcus multilocularis, Echinococcus multilocularis Nemuro
Manually annotated by BRENDA team
Mercado-Lubo, R.; Gauger, E.J.; Leatham, M.P.; Conway, T.; Cohen, P.S.
A Salmonella enterica serovar typhimurium succinate dehydrogenase/fumarate reductase double mutant is avirulent and immunogenic in BALB/c mice
Infect. Immun.
76
1128-1134
2008
Salmonella enterica
Manually annotated by BRENDA team
Buettner, F.F.; Bendallah, I.M.; Bosse, J.T.; Dreckmann, K.; Nash, J.H.; Langford, P.R.; Gerlach, G.F.
Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence
Infect. Immun.
76
2284-2295
2008
Actinobacillus pleuropneumoniae
Manually annotated by BRENDA team
Iwata, F.; Shinjyo, N.; Amino, H.; Sakamoto, K.; Islam, M.K.; Tsuji, N.; Kita, K.
Change of subunit composition of mitochondrial complex II (succinate-ubiquinone reductase/quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host
Parasitol. Int.
57
54-61
2008
Ascaris suum
Manually annotated by BRENDA team
Shiomi, K.; Hatano, H.; Morimoto, H.; Ui, H.; Sakamoto, K.; Kita, K.; Tomoda, H.; Lee, E.W.; Heo, T.R.; Kawagishi, H.; Omura, S.
Decursin and decursinol angelate selectively inhibit NADH-fumarate reductase of Ascaris suum
Planta Med.
73
1478-1481
2007
Ascaris suum
Manually annotated by BRENDA team
Camarasa, C.; Faucet, V.; Dequin, S.
Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1
Yeast
24
391-401
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Osanai, A.; Harada, S.; Sakamoto, K.; Shimizu, H.; Inaoka, D.K.; Kita, K.
Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil
Acta Crystallogr. Sect. F
65
941-944
2009
Ascaris suum
Manually annotated by BRENDA team
Pessanha, M.; Rothery, E.L.; Miles, C.S.; Reid, G.A.; Chapman, S.K.; Louro, R.O.; Turner, D.L.; Salgueiro, C.A.; Xavier, A.V.
Tuning of functional heme reduction potentials in Shewanella fumarate reductases
Biochim. Biophys. Acta
1787
113-120
2009
Shewanella oneidensis, Shewanella frigidimarina, Shewanella frigidimarina NCIMB400, Shewanella oneidensis MR-1 / ATCC 700550
Manually annotated by BRENDA team
Vieites, M.; Smircich, P.; Parajon-Costa, B.; Rodriguez, J.; Galaz, V.; Olea-Azar, C.; Otero, L.; Aguirre, G.; Cerecetto, H.; Gonzalez, M.; Gomez-Barrio, A.; Garat, B.; Gambino, D.
Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase
J. Biol. Inorg. Chem.
13
723-735
2008
Trypanosoma cruzi
Manually annotated by BRENDA team
Tomitsuka, E.; Kita, K.; Esumi, H.
The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
Ann. N. Y. Acad. Sci.
1201
44-49
2010
Homo sapiens
Manually annotated by BRENDA team
Weingarten, R.A.; Taveirne, M.E.; Olson, J.W.
The dual-functioning fumarate reductase is the sole succinate:quinone reductase in Campylobacter jejuni and is required for full host colonization
J. Bacteriol.
191
5293-5300
2009
Campylobacter jejuni (Q0PBA0), Campylobacter jejuni (Q0PBA1), Campylobacter jejuni (Q0PBA2), Campylobacter jejuni, Campylobacter jejuni NCTC 11168 (Q0PBA0), Campylobacter jejuni NCTC 11168 (Q0PBA1), Campylobacter jejuni NCTC 11168 (Q0PBA2)
Manually annotated by BRENDA team
Tomitsuka, E.; Kita, K.; Esumi, H.
Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit
Proc. Jpn. Acad. Ser. B
85
258-265
2009
Homo sapiens
Manually annotated by BRENDA team
Tomitsuka, E.; Kita, K.; Esumi, H.
An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments
J. Biochem.
152
171-183
2012
Homo sapiens
Manually annotated by BRENDA team
Edwards, C.; Copes, N.; Brito, A.; Canfield, J.; Bradshaw, P.
Malate and fumarate extend lifespan in Caenorhabditis elegans
PLoS ONE
8
e58345
2013
Caenorhabditis elegans
Manually annotated by BRENDA team
Mori, M.; Morimoto, H.; Kim, Y.; Ui, H.; Nonaka, K.; Masuma, R.; Sakamoto, K.; Kita, K.; Tomoda, H.; Shiomi, K.; Omura, S.
Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389
Tetrahedron
67
6582-6586
2011
Ascaris suum
-
Manually annotated by BRENDA team
Yang, L.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.
Enhanced succinic acid production in Aspergillus saccharolyticus by heterologous expression of fumarate reductase from Trypanosoma brucei
Appl. Microbiol. Biotechnol.
100
1799-1809
2016
Trypanosoma brucei (Q8ITL2), Trypanosoma brucei
Manually annotated by BRENDA team
Liu, W.C.; Wang, Y.Y.; Liu, J.H.; Ke, A.B.; Zheng, Z.H.; Lu, X.H.; Luan, Y.S.; Xiu, Z.L.; Dong, Y.S.
Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii
Bioorg. Med. Chem. Lett.
26
5328-5333
2016
Ascaris suum
Manually annotated by BRENDA team
Kaifuchi, S.; Mori, M.; Nonaka, K.; Masuma, R.; ?mura, S.; Shiomi, K.
Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713
J. Gen. Appl. Microbiol.
61
57-62
2015
Ascaris suum
Manually annotated by BRENDA team
Salusjaervi, L.; Kaunisto, S.; Holmstroem, S.; Vehkomaeki, M.L.; Koivuranta, K.; Pitkaenen, J.P.; Ruohonen, L.
Overexpression of NADH-dependent fumarate reductase improves D-xylose fermentation in recombinant Saccharomyces cerevisiae
J. Ind. Microbiol. Biotechnol.
40
1383-1392
2013
Trypanosoma brucei (Q8ITL2), Trypanosoma brucei
Manually annotated by BRENDA team
Kim, S.H.; Mamuad, L.L.; Kim, D.W.; Kim, S.K.; Lee, S.S.
Fumarate reductase-producing Enterococci reduce methane production in rumen fermentation in vitro
J. Microbiol. Biotechnol.
26
558-566
2016
Enterococcus faecalis, Enterococcus faecium, Enterococcus faecalis SROD5, Enterococcus faecium SROD
Manually annotated by BRENDA team
Merlino, A.; Vieites, M.; Gambino, D.; Coitino, E.L.
Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: ligand docking, molecular dynamics validation, and insights on their binding modes
J. Mol. Graph. Model.
48
47-59
2014
Leishmania major (E9AEQ8), Leishmania major, Trypanosoma cruzi (Q4CYX1), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4CYX1)
Manually annotated by BRENDA team