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1.3.1.70: DELTA14-sterol reductase

This is an abbreviated version!
For detailed information about DELTA14-sterol reductase, go to the full flat file.

Word Map on EC 1.3.1.70

Reaction

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol
+
NADP+
=
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
 +
NADPH
 +
H+

Synonyms

14-dehydrocholesterol reductase, 14-reductase, 14-SR, 3 beta-hydroxysterol-DELTA14-reductase, 3beta-hydroxysterol DELTA14-reductase, C-14 reductase, C-14 sterol reductase, C14-SR, C14-sterol reductase, C14SR, DELTA14-reductase, DELTA14-SR, DELTA14SR, DELTA7,14-steroid 14-reductase, DELTA7,14-sterol 14-reductase, DELTA7,14-sterol DELTA14-reductase, DELTA7,14-sterol-14-reductase, DELTA8,14-hydroxy steroid DELTA14(15)-reductase, DELTA8,14-steroid 14-reductase, DELTA8,14-sterol 14-reductase, DELTA8,14-sterol DELTA14-reductase, DELTA8,14-sterol-14-reductase, DHCR14, ERG 24, ERG24, erg24-1, erg24A, erg24B, fackel, FACKEL protein, FgERG24A, FgERG24B, FK, fk-J3158, integral membrane sterol reductase, lamin B receptor, lamin-B receptor, LBR, MaSR1, reductase, DELTA8,14-hydroxy steroid DELTA14(15)-, SR-1, sterol 14-reductase, sterol C-14 reductase, sterol C14-reductase, sterol DELTA14,15-reductase, sterol DELTA14-reductase, TM7SF2

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.70 DELTA14-sterol reductase

Reference

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Reference on EC 1.3.1.70 - DELTA14-sterol reductase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bottema, C.K.; Parks, L.W.
DELTA14-Sterol reductase in Saccharomyces cerevisiae
Biochim. Biophys. Acta
531
301-307
1978
Saccharomyces cerevisiae, Saccharomyces cerevisiae 3701B
Manually annotated by BRENDA team
Paik, Y.K.; Trzaskos, J.M.; Shafiee, A.; Gaylor, J.L.
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent DELTA8,14-steroid 14-reductase
J. Biol. Chem.
259
13413-13423
1984
Rattus norvegicus
Manually annotated by BRENDA team
Kim, C.K.; Jeon, K.I.; Lim, D.M.; Johng, T.N.; Trzaskos, J.M.; Gaylor, J.L.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase
Biochim. Biophys. Acta
1259
39-48
1995
Rattus norvegicus
Manually annotated by BRENDA team
Roberti, R.; Bennati, A.M.; Galli, G.; Caruso, D.; Maras, B.; Aisa, C.; Beccari, T.; Della Fazia, M.A.; Servillo, G.
Cloning and expression of sterol DELTA14-reductase from bovine liver
Eur. J. Biochem.
269
283-290
2002
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Taton, M.; Benveniste, P.; Rahier, A.
Microsomal DELTA8,14-sterol DELTA14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction
Eur. J. Biochem.
185
605-614
1989
Embryophyta, Zea mays
Manually annotated by BRENDA team
Lorenz, R.T.; Parks, L.W.
Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae
DNA Cell Biol.
11
685-692
1992
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Baloch, R.I.; Mercer, E.I.
Inhibition of sterol DELTA8 -> DELTA7-isomerase and DELTA14-reductase by fenpropimorph, tridemorph and fenpropidin in cell-free enzyme systems from Saccharomyces cerevisiae
Phytochemistry
26
663-668
1987
Saccharomyces cerevisiae, Ustilago maydis, Saccharomyces cerevisiae NCYC 739
-
Manually annotated by BRENDA team
Waterham, H.R.; Koster, J.; Mooyer, P.; Noort Gv, G.; Kelley, R.I.; Wilcox, W.R.; Wanders, R.J.; Hennekam, R.C.; Oosterwijk, J.C.
Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3beta-hydroxysterol DELTA14-reductase deficiency due to mutations in the lamin B receptor gene
Am. J. Hum. Genet.
72
1013-1017
2003
Homo sapiens (O76062), Homo sapiens (Q14739), Homo sapiens
Manually annotated by BRENDA team
Jia, N.; Arthington-Skaggs, B.; Lee, W.; Pierson, C.A.; Lees, N.D.; Eckstein, J.; Barbuch, R.; Bard, M.
Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site
Antimicrob. Agents Chemother.
46
947-957
2002
Candida albicans
Manually annotated by BRENDA team
Yamashita, Y.; Nishibori, M.; Terada, T.; Isobe, N.; Shimada, M.
Gonadotropin-induced DELTA14-reductase and DELTA7-reductase gene expression in cumulus cells during meiotic resumption of porcine oocytes
Endocrinology
146
186-194
2005
Sus scrofa
Manually annotated by BRENDA team
Prakash, A.; Kasbekar, D.P.
Genes encoding chimeras of Neurospora crassa erg-3 and human TM7SF2 proteins fail to complement Neurospora and yeast sterol C-14 reductase mutants
J. Biosci.
27
105-112
2002
Homo sapiens, Neurospora crassa
Manually annotated by BRENDA team
Prakash, A.; Kasbekar, D.P.
The sterol C-14 reductase encoded by the Neurospora crassa erg-3 gene: essential charged and polar residues identified by site-specific mutagenesis
Mol. Genet. Genomics
266
787-795
2002
Neurospora crassa
Manually annotated by BRENDA team
He, J.X.; Fujioka, S.; Li, T.C.; Kang, S.G.; Seto, H.; Takatsuto, S.; Yoshida, S.; Jang, J.C.
Sterols regulate development and gene expression in Arabidopsis
Plant Physiol.
131
1258-1269
2003
Arabidopsis thaliana
Manually annotated by BRENDA team
Bennati, A.M.; Castelli, M.; Della Fazia, M.A.; Beccari, T.; Caruso, D.; Servillo, G.; Roberti, R.
Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol DELTA14-reductase in human cholesterol biosynthesis
Biochim. Biophys. Acta
1761
677-685
2006
Homo sapiens
Manually annotated by BRENDA team
Shah Alam Bhuiyan, M.; Eckstein, J.; Barbuch, R.; Bard, M.
Synthetically lethal interactions involving loss of the yeast ERG24: the sterol C-14 reductase gene
Lipids
42
69-76
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Schiavoni, G.; Bennati, A.M.; Castelli, M.; Fazia, M.A.; Beccari, T.; Servillo, G.; Roberti, R.
Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box
Biochim. Biophys. Acta
1801
587-592
2010
Homo sapiens (O76062)
Manually annotated by BRENDA team
Wang, F.; Yang, J.; Wang, H.; Xia, G.
Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol DELTA14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads
Prostaglandins Other Lipid Mediat.
92
25-32
2010
Oryctolagus cuniculus
Manually annotated by BRENDA team
Liang, R.M.; CAO, YB.; Fan, K.H.; Xu, Y.; Gao, P.H.; Zhou, Y.J.; Tang, H.; Liu, H.T.; Jiang, Y.Y.
2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway
Acta Pharmacol. Sin.
30
1709
2009
Candida albicans
Manually annotated by BRENDA team
Hata, M.; Ishii, Y.; Watanabe, E.; Uoto, K.; Kobayashi, S.; Yoshida, K.; Otani, T.; Ando, A.
Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase
Med. Mycol.
48
613-621
2010
Candida albicans
Manually annotated by BRENDA team
Liu, X.; Fu, J.; Yun, Y.; Yin, Y.; Ma, Z.
A sterol C-14 reductase encoded by FgERG24B is responsible for the intrinsic resistance of Fusarium graminearum to amine fungicides
Microbiology
157
1665-1675
2011
Fusarium graminearum
Manually annotated by BRENDA team
Bartoli, D.; Piobbico, D.; Bellet, M.M.; Bennati, A.M.; Roberti, R.; Della Fazia, M.A.; Servillo, G.
Impaired cell proliferation in regenerating liver of 3beta-hydroxysterol DELTA14-reductase (TM7SF2) knock-out mice
Cell Cycle
15
2164-2173
2016
Mus musculus (Q71KT5)
Manually annotated by BRENDA team
Li, X.; Roberti, R.; Blobel, G.
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum
Nature
517
104-107
2015
Methylotuvimicrobium alcaliphilum (G4SW86), Methylotuvimicrobium alcaliphilum, Methylotuvimicrobium alcaliphilum 20Z (G4SW86), Methylotuvimicrobium alcaliphilum 20Z
Manually annotated by BRENDA team
Huang, B.; Qian, P.; Gao, N.; Shen, J.; Hou, S.
Fackel interacts with gibberellic acid signaling and vernalization to mediate flowering in Arabidopsis
Planta
245
939-950
2017
Arabidopsis thaliana (Q9LDR4)
Manually annotated by BRENDA team
Li, Y.; Dai, M.; Zhang, Y.; Lu, L.
The sterol C-14 reductase Erg24 is responsible for ergosterol biosynthesis and ion homeostasis in Aspergillus fumigatus
Appl. Microbiol. Biotechnol.
105
1253-1268
2021
Aspergillus fumigatus (B0XMW7), Aspergillus fumigatus (B0XP65), Aspergillus fumigatus, Aspergillus fumigatus FGSC A1163 (B0XMW7), Aspergillus fumigatus FGSC A1163 (B0XP65)
Manually annotated by BRENDA team
Hu, C.; Zhou, M.; Wang, W.; Sun, X.; Yarden, O.; Li, S.
Abnormal ergosterol biosynthesis activates transcriptional responses to antifungal azoles
Front. Microbiol.
9
9-9
2018
Neurospora crassa (P38670), Neurospora crassa DSM 1257 (P38670)
Manually annotated by BRENDA team
Capell-Hattam, I.M.; Sharpe, L.J.; Qian, L.; Hart-Smith, G.; Prabhu, A.V.; Brown, A.J.
Twin enzymes, divergent control The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
J. Biol. Chem.
295
2850-2865
2020
Homo sapiens (O76062), Homo sapiens (Q14739), Homo sapiens
Manually annotated by BRENDA team