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1.3.1.71: DELTA24(241)-sterol reductase

This is an abbreviated version!
For detailed information about DELTA24(241)-sterol reductase, go to the full flat file.

Word Map on EC 1.3.1.71

Reaction

ergosterol
+
NADP+
=
ergosta-5,7,22,24(241)-tetraen-3beta-ol
 +
NADPH
 +
H+

Synonyms

24-methylene sterol 24(28)-reductase, C-24(28) reductase, C-24(28) sterol reductase, C24(28) reductase, DELTA24(28)-sterol methylreductase, Erg4p, Erg6, S-adenosylmethionine:sterol C-24 methyltransferase, SAM:SMT, SMR, sterol DELTA24(28)-methylene reductase, sterol DELTA24(28)-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.71 DELTA24(241)-sterol reductase

Inhibitors

Inhibitors on EC 1.3.1.71 - DELTA24(241)-sterol reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20-piperidin-2-yl-5alpha-pregnan-20(R),3beta-diol
-
i.e. AZA-1, inhibits the enzyme and the DELTA24-sterol methyltransferase, leads to accumulation of ergosta-5,7,24(28)-trien-3beta-ol in vivo
22-piperidin-2-yl-5alpha-pregnan-3beta,22(S)-diol
-
i.e. AZA-2, specific inhibition of the enzyme, leads to accumulatin of ergosta-5,7,22,24(28)-tetraen-3beta-ol in vivo
22-piperidin-3-yl-5alpha-pregnan-3beta,22(S)-diol
-
i.e. AZA-3, inhibits the enzyme, major proliferative effect and accumulation of lanosterol in vivo
23-Azacholesterol
additional information
-
sterol composition with or without addition of azasterol analogue inhibitors, overview
-