1.3.1.74: 2-alkenal reductase [NAD(P)+]

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For detailed information about 2-alkenal reductase [NAD(P)+], go to the full flat file.

Word Map on EC 1.3.1.74

1.3.1.74

quercitrin

alpha,beta-unsaturated

dicumarol

2-alkenals

15-ketoprostaglandins

13-reductase

dihydrochalcone

acylfulvenes

Reaction

Synonyms

2-alkenal reductase, 2AER, AER, alkenal/one oxidoreductase, alkenal/one reductase, AOR, At-AER, At5g16970, AtAER, AtAOR, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, CS-670 double-bond reductase, CsAOR, Dbr1, double bond reductase, LTB4 12-HD/PGR, NADPH alkenal/one oxidoreductase, NADPH-dependent 2-alkenal reductase, NADPH-dependent alkenal/one oxidoreductase, ZmAER

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.74 2-alkenal reductase [NAD(P)+]

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Results	in table
6	Activating Compound
3442	AA Sequence
4	CAS Registry Number
12	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
8	Disease/ Diagnostics
1	Expression
2	General Information
16	Inhibitors
13	kcat/KM [mM/s]
1	Ki Value [mM]
51	KM Value [mM]
7	Localization
7	Metals/Ions
8	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
17	Organism
17	PDB ID
4	pH Optimum
2	pH Range
9	Purification (Commentary)
2	Reaction
3	Reaction Type
17	Reference
12	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
83	Substrates and Products (Substrate)
5	Subunits
29	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
38	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.3.1.74 - 2-alkenal reductase [NAD(P)+]

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15-keto prostaglandin F2alpha

Rattus norvegicus

43.06% residual activity at 0.1 mM

690204

2-nonanone

Rattus norvegicus

product inhibition, competitive versus trans-3-nonen-2-one

656210

benzylidene acetophenone

Rattus norvegicus

21.09% residual activity at 0.5 mM

cyclovalone

dicoumarol

11.45% residual activity at 0.1 mM

illudin M

illudin S

indomethacin

14.22% residual activity at 0.1 mM

690204

irofulven

Rattus norvegicus

recombinant human 293 cells show 100fold increased sensitivity compared to the wild-type human 293 cells

655242

NADP+

Rattus norvegicus

product inhibition, competitive versus NADPH

progesterone

quercetin

quercitrin

13.14% residual activity at 0.1 mM

690204

Zn2+

Rattus norvegicus

656210

additional information

2 entries