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1.3.1.76: precorrin-2 dehydrogenase

This is an abbreviated version!
For detailed information about precorrin-2 dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.76

Reaction

precorrin-2
+
NAD+
=
sirohydrochlorin
+
NADH
+
H+

Synonyms

cobaltochelatase, CysG, CysG enzyme, cysG gene product, CysG2, EC 2.1.1.107, Met8p, P2D, precorrin-2 dehydrogenase, S-adenosyl-L-methionine(SAM)-dependent bismethyltransferase, dehydrogenase and ferrochelatase, SirC, siroheme synthase, siroheme synthetase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.76 precorrin-2 dehydrogenase

Engineering

Engineering on EC 1.3.1.76 - precorrin-2 dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D141A
site-directed mutagenesis
G22D
site-directed mutagenesis
H237A
site-directed mutagenesis
K270I
-
site-directed mutagenesis
L250A
-
site-directed mutagenesis
N385A
-
site-directed mutagenesis
S128A
-
site-directed mutagenesis
S128D
-
site-directed mutagenesis
S128A
the variant is more active for dehydrogenation and chelation than wild type enzyme