1.3.1.86: crotonyl-CoA reductase

This is an abbreviated version!
For detailed information about crotonyl-CoA reductase, go to the full flat file.

Word Map on EC 1.3.1.86

Reaction

butanoyl-CoA
+
NADP+
=
(E)-but-2-enoyl-CoA
+
NADPH
+
H+

Synonyms

3-hydroxyacyl CoA reductase, acyl-CoA:NADP+ trans-2-oxidoreductase, bcd2, butanoyl-CoA:(acceptor) 2,3-oxidoreductase, butyryl coenzyme A dehydrogenase, butyryl dehydrogenase, butyryl-CoA dehydrogenase, butyryl-CoA dehydrogenase complex, CCR, CD1054, crotonyl CoA reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, crotonyl-coenzyme A reductase, enoyl-coenzyme A reductase, ethylene reductase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, trans-crotonyl CoA reductase, unsaturated acyl coenzyme A reductase, unsaturated acyl-CoA reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.86 crotonyl-CoA reductase

Inhibitors

Inhibitors on EC 1.3.1.86 - crotonyl-CoA reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
at high concentrations beta-mercaptoethanol is inhibitory
2-methylcrotonyl-CoA
-
CoA-activated enzyme shows competitive inhibition with the substrate analog 2-methylcrotonyl-CoA
4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole
-
extremely potent inhibitor
5,5'-dithiobis(2-nitrobenzoic acid)
-
extremely potent inhibitor
acetyl-CoA
-
competitive inhibitor
ammonium sulfate
-
enzyme activity is inhibited by ammonium sulfatehowever, this inhibition is overcome by addition of 10 mM guanidine
arachidoyl-CoA
-
86% residual activity at 0.1 mM
butyryl-CoA
Ca2+
-
complete inhibition at 1 mM
Co2+
-
complete inhibition at 1 mM
dithiothreitol
-
at high concentrations dithiothreitol is inhibitory
iodoacetamide
iodoacetate
-
-
isomyristoyl-CoA
-
78% residual activity at 0.1 mM
isopalmitoyl-CoA
-
95% residual activity at 0.1 mM
malonyl-CoA
-
noncompetitive inhibitor
Mg2+
-
30% inhibition at 1 mM
Mn2+
-
complete inhibition at 1 mM
myristoyl-CoA
-
36% residual activity at 0.1 mM
N-ethylmaleimide
NADPH
-
concentrations of NADPH above 0.2 mM lead to inhibition of enzyme activity
p-chloromercuribenzoate
-
a 30-min incubation of crotonyl-CoA reductase with p-chloromercuribenzoate at 0.008 mM leads to approximately 8.5% inhibition of enzyme activity
palmitoyl-CoA
-
24% residual activity at 0.1 mM
stearoyl-CoA
-
92% residual activity at 0.1 mM
Zn2+
-
55% inhibition at 1 mM
additional information
-
no significant inhibition of the activity of crotonyl-CoA reductase is observed upon addition of either flavin adenine dinucleotide (0.018 and 0.072 mM) or flavin mononucleotide (0.013 and 0.130 mM)
-