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1.3.1.88: tRNA-dihydrouridine16/17 synthase [NAD(P)+]

This is an abbreviated version!
For detailed information about tRNA-dihydrouridine16/17 synthase [NAD(P)+], go to the full flat file.

Reaction

5,6-dihydrouracil16 in tRNA
+
NAD(P)+
=
uracil16 in tRNA
+
NAD(P)H
+
H+

Synonyms

Dus1p, tRNA-dihydrouridine synthase 1

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.88 tRNA-dihydrouridine16/17 synthase [NAD(P)+]

General Information

General Information on EC 1.3.1.88 - tRNA-dihydrouridine16/17 synthase [NAD(P)+]

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast