1.3.1.92: artemisinic aldehyde DELTA11(13)-reductase

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For detailed information about artemisinic aldehyde DELTA11(13)-reductase, go to the full flat file.

Reaction

Synonyms

artemisinic aldehyde DELTA11(13) double bond reductase2, artemisinic aldehyde DELTA11(13) double-bond reductase, artemisinic aldehyde DELTA11(13) reductase, Dbr2, double bond reductase 2, double-bond reductase 2

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.92 artemisinic aldehyde DELTA11(13)-reductase

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Results

in table

1

Activating Compound

1

AA Sequence

4

Application

8

Cloned(Commentary)

8

Cofactor

6

Expression

4

General Information

5

kcat/KM [mM/s]

5

KM Value [mM]

1

Localization

1

Molecular Weight [Da]

8

Natural Substrates/ Products (Substrates)

14

Organism

3

Pathway

4

PDB ID

1

pH Optimum

2

pH Range

3

Protein Variants

1

Purification (Commentary)

1

Reaction

14

Reference

15

Source Tissue

19

Substrates and Products (Substrate)

17

Synonyms

1

Systematic Name

5

Turnover Number [1/s]

General Information

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General Information on EC 1.3.1.92 - artemisinic aldehyde DELTA11(13)-reductase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

2 entries

physiological function

2 entries

metabolism

Artemisia annua

C5H429

artemisinic aldehyde 11 (13) reductase (DBR2) is the checkpoint enzyme catalyzing artemisinic aldehyde to form dihydroartemisinic aldehyde directly involved in artemisinin biosynthetic pathway

744537

metabolism

Artemisia annua

C5H429

the final step of artemisin biosynthesis involves two genes, a double bond reductase (DBR2) and an aldehyde dehydrogenase (ALDH1)

744971

physiological function

Artemisia annua

-

the early steps in artemisinin biosynthesis involve amorpha-4,11-diene hydroxylation to artemisinic alcohol, followed by oxidation to artemisinic aldehyde, reduction of the C11-C13 double bond to dihydroartemisinic aldehyde and oxidation to dihydroartemisinic acid

718241

physiological function

Artemisia annua

C5H429

the enzyme plays an important role in the biosynthesis of the antimalarial artemisinin in Artemisia annua. The high artemisin producing plant varieties 2/39, Chongqing, and Anamed produce more artemisinin than arteannuin B, while the low artemisin producing plant varieties Meise, Iran#8, Iran#14, Iran#24, and Iran#47 produce more arteannuin B than artemisinin

746092