1.3.1.94: polyprenol reductase
This is an abbreviated version!
For detailed information about polyprenol reductase, go to the full flat file.
Word Map on EC 1.3.1.94
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1.3.1.94
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dolichols
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polyprenols
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pmm2-cdg
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atp6v0a2
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cis-prenyltransferase
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coloboma
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alpha-dihydrotestosterone
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srd5as
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medicine
- 1.3.1.94
- dolichols
- polyprenols
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pmm2-cdg
-
atp6v0a2
- cis-prenyltransferase
-
coloboma
-
alpha-dihydrotestosterone
-
srd5as
- medicine
Reaction
Synonyms
DFG10, PPRD, SDR5A3, SRD5A3, steroid 5alpha-reductase type 3
ECTree
1.3.1.94 polyprenol reductaseAdvanced search results
results (
results (| Results | in table |
|---|---|
| 2985 | AA Sequence |
| 1 | Application |
| 1 | CAS Registry Number |
| 3 | Cloned(Commentary) |
| 49 | Disease/ Diagnostics |
| 3 | General Information |
| 1 | Localization |
| 3 | Natural Substrates/ Products (Substrates) |
| 5 | Organism |
| 5 | Pathway |
| 1 | pH Optimum |
| 1 | Reaction |
| 5 | Reference |
| 1 | Source Tissue |
| 7 | Substrates and Products (Substrate) |
| 7 | Synonyms |
| 1 | Systematic Name |
General Information
General Information on EC 1.3.1.94 - polyprenol reductase
for references in articles please use BRENDA:EC1.3.1.94
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
physiological function
physiological function
enzyme is necessary for the reduction of the alpha-isoprene unit of polyprenols to form dolichols, required for synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation
physiological function
Srd5a3 mutation is lethal in mouse and results in an activation of the unfolded protein response pathway
physiological function
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the activities of yeast cis-prenyltransferases Rer2p and Srt1p and polyprenol reductase are not co-regulated and the reductase may be the rate-limiting enzyme in dolichol synthesis if the amount of polyisoprenoids synthesized exceeds a certain level
