1.3.1.98: UDP-N-acetylmuramate dehydrogenase

This is an abbreviated version!
For detailed information about UDP-N-acetylmuramate dehydrogenase, go to the full flat file.

Reaction

Synonyms

alr5066, EC 1.1.1.158, More, MurB, MurBAb, PA2977, PaMurB, reductase, uridine diphosphoacetylpyruvoylglucosamine, type I UNAGEP reductase, UDP-GlcNAc-enoylpyruvate reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylenolpyruvyl glucosamine reductase, UDP-N-acetylenolpyruvylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-N-acetylmuramate dehydrogenase, UNAGEP reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase, VspiD_010100018130

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.98 UDP-N-acetylmuramate dehydrogenase

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Results

in table

2

Activating Compound

42793

AA Sequence

1

Application

1

CAS Registry Number

13

Cloned(Commentary)

45

Cofactor

7

Crystallization (Commentary)

18

Engineering

8

General Information

2

General Stability

28

IC50 Value

269

Inhibitors

24

KM Value [mM]

5

Localization

33

Metals/Ions

10

Molecular Weight [Da]

29

Natural Substrates/ Products (Substrates)

230

Organism

1

Oxidation Stability

8

Pathway

7

PDB ID

10

pH Optimum

2

pH Range

1

pH Stability

15

Purification (Commentary)

5

Reaction

3

Reaction Type

40

Reference

5

Specific Activity [micromol/min/mg]

4

Storage Stability

42

Substrates and Products (Substrate)

10

Subunits

64

Synonyms

1

Systematic Name

3

Temperature Optimum [°C]

3

Temperature Range [°C]

2

Temperature Stability [°C]

Synonyms

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Synonyms on EC 1.3.1.98 - UDP-N-acetylmuramate dehydrogenase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

alr5066

2 entries

EC 1.1.1.158

4 entries

MurB

19 entries

MurBAb

Verrucomicrobium spinosum

-

-

744976

PA2977

Pseudomonas aeruginosa

Q9HZM7

-

746242

PaMurB

Pseudomonas aeruginosa

Q9HZM7

-

746242

reductase, uridine diphosphoacetylpyruvoylglucosamine

-

-

-

-

type I UNAGEP reductase

Pseudomonas aeruginosa

Q9HZM7

-

746242

UDP-GlcNAc-enoylpyruvate reductase

-

-

-

-

UDP-N-acetylenolpyruvoylglucosamine reductase

5 entries

UDP-N-acetylenolpyruvyl glucosamine reductase

9 entries

UDP-N-acetylenolpyruvylglucosamine reductase

6 entries

UDP-N-acetylglucosamine-enoylpyruvate reductase

-

-

-

-

UDP-N-acetylmuramate dehydrogenase

-

-

-

-

UNAGEP reductase

Pseudomonas aeruginosa

Q9HZM7

-

746242

uridine diphospho-N-acetylglucosamine-enolpyruvate reductase

-

-

-

-

uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase

-

-

-

-

VspiD_010100018130

Verrucomicrobium spinosum

-

locus name

744976

additional information

Thermus caldophilus

Q5SJC8

a type II enzyme lacking Tyr loop and split betaalphabetabeta fold

689925

alr5066

Anabaena sp.

Q8YM74

-

745220

alr5066

Anabaena sp. PCC 7120

Q8YM74

-

-

EC 1.1.1.158

Escherichia coli

-

formerly

722831

EC 1.1.1.158

Mycobacterium tuberculosis

-

formerly

722410

EC 1.1.1.158

Mycobacterium tuberculosis

P9WJL9

formerly

723008

EC 1.1.1.158

Mycobacterium tuberculosis H37Rv

P9WJL9

formerly

-

MurB

Anabaena sp.

Q8YM74

-

745220

MurB

Anabaena sp. PCC 7120

Q8YM74

-

-

MurB

Candida albicans

-

-

669810

MurB

Enterococcus faecalis

-

-

669810

MurB

Enterococcus faecalis GC 2242

-

-

-

MurB

Escherichia coli

-

-

669810, 722831

MurB

Escherichia coli GC 4560 imp

-

-

-

MurB

Mycobacterium tuberculosis

-

-

698345, 722410

MurB

Mycobacterium tuberculosis

P9WJL9

-

723008

MurB

Mycobacterium tuberculosis H37Rv

P9WJL9

-

-

MurB

Pseudomonas aeruginosa

Q9HZM7

-

746242

MurB

Staphylococcus aureus

-

-

286071, 669810

MurB

Staphylococcus aureus

P61431

-

669466

MurB

Staphylococcus aureus GC 1131

-

-

-

MurB

Streptococcus pneumoniae

-

-

669810

MurB

Streptococcus pneumoniae GC 1894

-

-

-

MurB

Thermus caldophilus

Q5SJC8

-

689925

MurB

Verrucomicrobium spinosum

-

-

744976

MurB

Verrucomicrobium spinosum DSM 4136

-

-

-

UDP-N-acetylenolpyruvoylglucosamine reductase

-

-

-

-

UDP-N-acetylenolpyruvoylglucosamine reductase

Anabaena sp.

Q8YM74

-

745220

UDP-N-acetylenolpyruvoylglucosamine reductase

Anabaena sp. PCC 7120

Q8YM74

-

-

UDP-N-acetylenolpyruvoylglucosamine reductase

Verrucomicrobium spinosum

-

-

744976

UDP-N-acetylenolpyruvoylglucosamine reductase

Verrucomicrobium spinosum DSM 4136

-

-

-

UDP-N-acetylenolpyruvyl glucosamine reductase

Candida albicans

-

-

669810

UDP-N-acetylenolpyruvyl glucosamine reductase

Enterococcus faecalis

-

-

669810

UDP-N-acetylenolpyruvyl glucosamine reductase

Enterococcus faecalis GC 2242

-

-

-

UDP-N-acetylenolpyruvyl glucosamine reductase

Escherichia coli

-

-

669810

UDP-N-acetylenolpyruvyl glucosamine reductase

Escherichia coli GC 4560 imp

-

-

-

UDP-N-acetylenolpyruvyl glucosamine reductase

Staphylococcus aureus

-

-

669810

UDP-N-acetylenolpyruvyl glucosamine reductase

Staphylococcus aureus GC 1131

-

-

-

UDP-N-acetylenolpyruvyl glucosamine reductase

Streptococcus pneumoniae

-

-

669810

UDP-N-acetylenolpyruvyl glucosamine reductase

Streptococcus pneumoniae GC 1894

-

-

-

UDP-N-acetylenolpyruvylglucosamine reductase

Escherichia coli

-

-

722831

UDP-N-acetylenolpyruvylglucosamine reductase

Mycobacterium tuberculosis

-

-

722410

UDP-N-acetylenolpyruvylglucosamine reductase

Mycobacterium tuberculosis H37Rv

-

-

-

UDP-N-acetylenolpyruvylglucosamine reductase

Staphylococcus aureus

-

-

286071

UDP-N-acetylenolpyruvylglucosamine reductase

Staphylococcus aureus

P61431

-

669466

UDP-N-acetylenolpyruvylglucosamine reductase

Thermus caldophilus

Q5SJC8

-

689925