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1.3.3.5: bilirubin oxidase

This is an abbreviated version!
For detailed information about bilirubin oxidase, go to the full flat file.

Word Map on EC 1.3.3.5

Reaction

2 bilirubin +

O2
= 2 biliverdin + 2 H2O

Synonyms

bilirubin oxidase, bilirubin oxidase M-1, bilirubin:oxygen oxidoreductase, blue Cu enzyme, BOD, BODx, BOX, BPUM_0542, copper oxidase, CotA, MCO, multicopper oxidase, MvBO, MvBOD, oxidase, bilirubin

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.5 bilirubin oxidase

Inhibitors

Inhibitors on EC 1.3.3.5 - bilirubin oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
15.21% residual activity at 5 mM
acetone
81.18% residual activity at 50% (v/v)
acetonitrile
69.02% residual activity at 50% (v/v)
albumin
-
Antimycin
-
-
bilirubin
-
0.09 mM, complete inhibition of enzyme activity in 50 : 50 chloroform-n-heptane two-phase system
bromosulphothalein
-
1 mM, 60% inhibition
Ca2+
84.91% residual activity at 10 mM
chloride
might inhibit the enzyme
cysteine
-
1 mM, 40% inhibition
Digitonin
-
0.1%, 50% inhibition
dimethyl sulfoxide
68.04% residual activity at 50% (v/v)
dimethylformamide
55.72% residual activity at 50% (v/v)
dithiothreitol
ethanol
70.42% residual activity at 50% (v/v)
Fe3+
52.1% residual activity at 5 mM
guanidinium hydrochloride
-
reversible inactivation at 1 M, pH 7.0, kinetics, overview
hydrogen peroxide
-
KCl
-
50 mM, 40% inhibition
L-cysteine
-
87% inhibition at 1 mM, no significant effect at 0.1 mM
mercaptoethanol
-
1 mM, 50% inhibition
methanol
78.29% residual activity at 50% (v/v)
Mg2+
85.36% residual activity at 10 mM
MgCl2
-
50 mM, 52% inhibition
Mn2+
65.77% residual activity at 10 mM
NaN3
-
76% inhibition at 10 mM
Remazol Brilliant Blue R
-
substrate inhibition above 100 mg/l
rotenone
-
-
SDS
41.42% residual activity at 0.1 mM
Sodium azide
sodium taurocholate
-
0.5%, 50% inhibition
Thiourea
-
0.1 mM, 15% inhibition
Triton X-100
98.75% residual activity at 5 mM
Urate
Zn2+
80.19% residual activity at 10 mM
additional information
-