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1.3.3.6: acyl-CoA oxidase

This is an abbreviated version!
For detailed information about acyl-CoA oxidase, go to the full flat file.

Word Map on EC 1.3.3.6

Reaction

acyl-CoA
+
O2
=
trans-2,3-dehydroacyl-CoA
 +
H2O2

Synonyms

3alpha,7alpha, 12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase, ACO, ACO I, ACO-A1, ACO-I, ACO-II, ACOX, ACOX-1, ACOX-1.1, ACOX-1.2, ACOX-1.3, ACOX-2, ACOX-3, ACOX1, ACOX1-3I, ACOX1a, ACOX1b, ACOX1–3II, ACOX2, ACOX3, ACX, ACX1, ACX1.2, ACX2, ACX3, ACX4, ACX5, acyl coenzyme A oxidase, acyl-CoA dehydrogenase, Acyl-CoA oxidase, acyl-CoA oxidase 1, acyl-CoA oxidase 1a, acyl-CoA oxidase 1b, acyl-CoA oxidase 2, acyl-CoA oxidase 4, acyl-CoA oxidase I, acyl-CoA oxidase-1, acyl-CoA oxidase-II, acyl-CoA-oxidase, acyl-coenzyme A oxidase, acyl-coenzyme A oxidase 1, acyl-coenzyme A oxidase 4, acyl-coenzyme A: oxygen oxidoreductase, AOX, AOX1, AOX2, Aox2p, AOX3, Aox3p, AOX4, aoxA, Aoxp, AtACX1, AtACX2, AtACX3, AtSACX, BRCACox, CrACX2, Cre05.g232002, fatty acyl-CoA oxidase, fatty acyl-coenzyme A oxidase, long chain acyl-CoA oxidase, long chain fatty acyl coenzyme A oxidase, long chain fatty acyl-CoA oxidase, long-chain-specific acyl-CoA oxidase 1, MCAD Y375K, MCOX, oxidase, acyl-coenzyme A, palmitoyl-CoA oxidase, peroxisomal acyl-coenzyme A oxidase, Peroxisomal fatty acyl-CoA oxidase, POX1, Pox1p, POX4, PpACX1, Pristanoyl-CoA oxidase, SCOX, short chain-specific acyl-CoA oxidase, short-chain acyl-CoA oxidase, straight chain acyl-CoA oxidase, straight-chain acyl-coenzyme A oxidase, THCA-CoA oxidase, THCCox, Trihydroxycoprostanoyl-CoA oxidase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.6 acyl-CoA oxidase

Expression

Expression on EC 1.3.3.6 - acyl-CoA oxidase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
high temperature and low food availability conditions induce the expression of acox-2 and/or acox-3 and lead to corresponding changes in ascaroside production
increased renal isoform ACOX2 activity is associated with the onset of hypertension
-
isoform Acox-1.1 is highly transcribed in the egg and diapause stages, particularly in the latter. Isoform Acox-1.2 is predominantly transcribed in the egg, L1, L2 and L3 stages collected from the environment while transcribed at low level in the diapause stage collected from the host animals. Isoform Acox-1.3 is highly transcribed in the early developmental stages
isoform ACX1 transcripts are up-regulated during flower opening
the hydrogen peroxide-generating enzyme ACOX1 is inducible under conditions of high-fat diet or exposure to PPARalpha ligands, which results in a net increase of hydrogen peroxide in peroxisomes