1.3.4.1: fumarate reductase (CoM/CoB)

This is an abbreviated version!
For detailed information about fumarate reductase (CoM/CoB), go to the full flat file.

Reaction

fumarate
+
CoM
+
CoB
=
succinate
+
CoM-S-S-CoB

Synonyms

Tfr, thiol:fumarate reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.4 With a disulfide as acceptor
                1.3.4.1 fumarate reductase (CoM/CoB)

Systematic Name

Systematic Name on EC 1.3.4.1 - fumarate reductase (CoM/CoB)

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SYSTEMATIC NAME
IUBMB Comments
fumarate CoM:CoB oxidoreductase (succinate forming)
The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)].