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1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
 +
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

Specific Activity

Specific Activity on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002672
-
37°C
0.0017
pH 7.4, 25°C
0.0026
0.0054
0.0066
-
heart
0.0078
-
heart
0.015
-
EAT cells
1.1 - 23
1.1 - 7.7
1.49
-
-
103
-
-
119000
-
cosubstrate O2, pH 7.5
130
-
expressed in SF21 insect cells
130 - 150
-
-
20 - 24
245000
-
cosubstrate 2,6-dichlorophenolindophenol, pH 7.5
548000
-
cosubstrate Q1, pH 7.5
6
using decylubiquinone and 2,6-dichloroindophenol as acceptor
69
recombinant full-length enzyme, pH 8.0, 30°C
7.4 - 58
83
-
expressed in Escherichia coli
84
-
pH 8.0, 30°C
9.1 - 14.5
9.6
-
recombinant enzyme, electron acceptor decylubiquinone
94
recombinant N-terminally truncated enzyme, pH 8, 30°C
99
with L-dihydroorotate and 2,6-dichloroindophenol as substrates, at 30°C
additional information
highest activities in ileum and colon