1.3.7.11: 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
This is an abbreviated version!
For detailed information about 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase, go to the full flat file.
Reaction
Synonyms
AF0464, CrtI homologue, digeranylgeranylglycerophospholipid reductase, EC 1.3.99.34, geranylgeranyl reductase, GGR, MA1484, MA1492, MA_1484, MA_1492, phytoene dehydrogenase family protein, Sa-GGR, SaGGR, Ta0516
ECTree
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39
Reference
Reference on EC 1.3.7.11 - 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
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Xu, Q.; Eguchi, T.; Mathews, I.I.; Rife, C.L.; Chiu, H.J.; Farr, C.L.; Feuerhelm, J.; Jaroszewski, L.; Klock, H.E.; Knuth, M.W.; Miller, M.D.; Weekes, D.; Elsliger, M.A.; Deacon, A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A.
Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids
J. Mol. Biol.
404
403-417
2010
Thermoplasma acidophilum (Q9HKS9)

Murakami, M.; Shibuya, K.; Nakayama, T.; Nishino, T.; Yoshimura, T.; Hemmi, H.
Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus
FEBS J.
274
805-814
2007
Archaeoglobus fulgidus (O29786), Archaeoglobus fulgidus

Sato, S.; Murakami, M.; Yoshimura, T.; Hemmi, H.
Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product
J. Bacteriol.
190
3923-3929
2008
Sulfolobus acidocaldarius (Q4JA33)

Sasaki, D.; Fujihashi, M.; Iwata, Y.; Murakami, M.; Yoshimura, T.; Hemmi, H.; Miki, K.
Structure and mutation analysis of archaeal geranylgeranyl reductase
J. Mol. Biol.
409
543-557
2011
Sulfolobus acidocaldarius (Q4JA33)

Ogawa, T.; Isobe, K.; Mori, T.; Asakawa, S.; Yoshimura, T.; Hemmi, H.
A novel geranylgeranyl reductase from the methanogenic archaeon Methanosarcinaacetivorans displays unique regiospecificity
FEBS J.
281
3165-3176
2014
Methanosarcina acetivorans (Q8TQP8), Methanosarcina acetivorans, Methanosarcina acetivorans DSM 2834 (Q8TQP8)

Isobe, K.; Ogawa, T.; Hirose, K.; Yokoi, T.; Yoshimura, T.; Hemmi, H.
Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells
J. Bacteriol.
196
417-423
2014
Methanosarcina acetivorans (Q8TQQ6), Methanosarcina acetivorans DSM 2834 (Q8TQQ6)

Kung, Y.; McAndrew, R.P.; Xie, X.; Liu, C.C.; Pereira, J.H.; Adams, P.D.; Keasling, J.D.
Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase
Structure
22
1028-1036
2014
Sulfolobus acidocaldarius (Q4JA33), Sulfolobus acidocaldarius DSM 639 (Q4JA33)

Meadows, C.; Mingardon, F.; Garabedian, B.; Baidoo, E.; Benites, V.; Rodrigues, A.; Abourjeily, R.; Chanal, A.; Lee, T.
Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity
Biotechnol. Biofuels
11
340
2018
Methanobrevibacter ruminantium (D3E3T0), Methanocaldococcus infernus (D5VQY0), Methanococcoides burtonii (Q12WF0), Methanosarcina acetivorans (Q8TQQ6), Thermoplasma acidophilum (Q9HKS9), Thermococcus nautili (W8NRH6), Methanobrevibacter ruminantium DSM 1039 (D3E3T0), Methanosarcina acetivorans DSM 2834 (Q8TQQ6), Methanocaldococcus infernus DSM 11812 (D5VQY0), Methanococcoides burtonii DSM 6242 (Q12WF0)

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