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1.3.7.11: 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

This is an abbreviated version!
For detailed information about 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase, go to the full flat file.

Reaction

a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid
+ 16 oxidized ferredoxin [iron-sulfur] cluster =
a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid
 + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+

Synonyms

AF0464, CrtI homologue, digeranylgeranylglycerophospholipid reductase, EC 1.3.99.34, geranylgeranyl reductase, GGR, MA1484, MA1492, MA_1484, MA_1492, phytoene dehydrogenase family protein, Sa-GGR, SaGGR, Ta0516

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.7 With an iron-sulfur protein as acceptor
                1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

Systematic Name

Systematic Name on EC 1.3.7.11 - 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

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SYSTEMATIC NAME
IUBMB Comments
2,3-bis-(O-phytanyl)-sn-glycero-phospholipid:ferredoxin oxidoreductase
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].