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1.3.8.12: (2S)-methylsuccinyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about (2S)-methylsuccinyl-CoA dehydrogenase, go to the full flat file.

Reaction

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(2S)-methylsuccinyl-CoA
+
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electron-transfer flavoprotein
=
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2-methylfumaryl-CoA
+
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reduced electron-transfer flavoprotein

Synonyms

MCD, methylsuccinyl-CoA dehydrogenase, PdMCD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                EC 1.3.8.121.3.8.12 (2S)-methylsuccinyl-CoA dehydrogenase

Engineering

Engineering on EC 1.3.8.12 - (2S)-methylsuccinyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.12

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E377N
site-directed mutagenesis, the mutant does not show increased oxidase activity although reduced dehydrogenase activity compared to wild-type
M375S
site-directed mutagenesis, the mutant is inactive as oxidase
T317G
site-directed mutagenesis, the mutant shows increased oxidase activity and reduced dehydrogenase activity compared to wild-type. The mutant directly reacts with O2
W315F
site-directed mutagenesis, the mutant does not show increased oxidase activity although reduced dehydrogenase activity compared to wild-type
W315F/T317G/E377N
site-directed mutagenesis, the mutant shows increased oxidase activity and reduced dehydrogenase activity compared to wild-type. The mutant directly reacts with O2
Y372I
site-directed mutagenesis, the mutant is inactive as oxidase
Y378G
site-directed mutagenesis, the mutant is inactive as oxidase
A282F
A282F/F284A
A282F/F284L
A282F/F284V
A282I
A282L
A282V
A282L
A282V
additional information