1.3.8.6: glutaryl-CoA dehydrogenase (ETF)

This is an abbreviated version!
For detailed information about glutaryl-CoA dehydrogenase (ETF), go to the full flat file.

Word Map on EC 1.3.8.6

1.3.8.6

glutaric

aciduria

3-hydroxyglutaric

striatal

dystonia

encephalopathic

ga1

macrocephaly

inborn

neurometabolic

crises

glutarylcarnitine

hydroxylysine

carnitine

crotonyl-coa

glutaconic

intercurrent

3-oh-ga

frontotemporal

neuroradiological

acylcarnitine

excretors

medicine

glutaconyl-coa

acidaemia

subdural

isovaleryl-coa

glutarylation

sylvian

pharmacology

Reaction

Synonyms

decarboxylating glutaryl-coenzyme A dehydrogenase, EC 1.3.99.7, GCD, GCDH, GDH, GDHGeo, glutaryl coenzyme A dehydrogenase, glutaryl-CoA dehydrogenase, glutaryl-coenzyme A dehydrogenase, More

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.8 With a flavin as acceptor

1.3.8.6 glutaryl-CoA dehydrogenase (ETF)

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Results	in table
1	Activating Compound
1542	AA Sequence
9	Application
1	CAS Registry Number
8	Cloned(Commentary)
26	Cofactor
4	Crystallization (Commentary)
349	Disease/ Diagnostics
21	General Information
15	Inhibitors
5	kcat/KM [mM/s]
3	Ki Value [mM]
44	KM Value [mM]
15	Localization
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
253	Organism
9	Pathway
11	pH Optimum
1	pH Range
1	pH Stability
39	Protein Variants
16	Purification (Commentary)
5	Reaction
6	Reaction Type
51	Reference
49	Source Tissue
17	Specific Activity [micromol/min/mg]
1	Storage Stability
90	Substrates and Products (Substrate)
9	Subunits
39	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
6	Temperature Stability [°C]
30	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.3.8.6 - glutaryl-CoA dehydrogenase (ETF)

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glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)

Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC 1.3.99.32, glutaryl-CoA dehydrogenase (acceptor)].