1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, EC 1.3.99.3, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.8 With a flavin as acceptor

                1.3.8.7 medium-chain acyl-CoA dehydrogenase

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Results	in table
2	Activating Compound
12485	AA Sequence
13	Application
1	CAS Registry Number
19	Cloned(Commentary)
28	Cofactor
8	Crystallization (Commentary)
2577	Disease/ Diagnostics
9	General Information
3	General Stability
58	Inhibitors
14	Ki Value [mM]
117	KM Value [mM]
17	Localization
25	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
120	Organism
10	Pathway
4	PDB ID
7	pH Optimum
4	pH Range
1	pH Stability
78	Protein Variants
29	Purification (Commentary)
9	Reaction
5	Reaction Type
114	Reference
73	Source Tissue
19	Specific Activity [micromol/min/mg]
11	Storage Stability
210	Substrates and Products (Substrate)
19	Subunits
83	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
16	Temperature Stability [°C]
84	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

rosiglitazone

Mus musculus

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treatment with 10 mg per kg and day increases acyl-CoA dehydrogenase expression and activity in both epididymal and inguinal white adipose tissue but not in brown adipose tissue, liver or muscle. The effect is the same in wild-type and PPAR-alpha knock-out mice

700516

additional information

Rattus norvegicus

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administration of a high fat diet in heart failure rats increases MCAD activity

685980

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