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1.3.8.9: very-long-chain acyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about very-long-chain acyl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.9

Reaction

a very-long-chain acyl-CoA
+
electron-transfer flavoprotein
=
a very-long-chain trans-2,3-dehydroacyl-CoA
 +
reduced electron-transfer flavoprotein

Synonyms

ACADVL, acyl-CoA:(acceptor) 2,3-oxidoreductase, EC 1.3.99.3, MCAD, very long chain acyl-CoA dehydrogenase, very long-chain acyl-CoA dehydrogenase, very-long-chain acyl-CoA dehydrogenase, VLCAD, VLCADD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.9 very-long-chain acyl-CoA dehydrogenase

Systematic Name

Systematic Name on EC 1.3.8.9 - very-long-chain acyl-CoA dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.