1.3.99.23: all-trans-retinol 13,14-reductase
This is an abbreviated version!
For detailed information about all-trans-retinol 13,14-reductase, go to the full flat file.
Reaction
Synonyms
(13,14)-all-trans-retinol saturase, 13,14-dihydroretinol saturase, all-trans-13,14-dihydroretinol saturase, all-trans-retinol:all-trans-13,14-dihydroretinol saturase, rat mammary tumor 7, retinol saturase, RetSat, RetSat A, Rmt7
ECTree
Advanced search results
Application
Application on EC 1.3.99.23 - all-trans-retinol 13,14-reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
analysis
-
the mouse pluripotent P-19 cell metabolizes retinol to atRA and thus can be used in a cell-based screen for disruptors of the pathway. The disruption of the pathway is easily detected and quantitated, the P-19 cell provides an in vitro model system for identifying and exploring the mechanism of action of chemicals that interfere with the critical cellular pathway
medicine
additional information
-
RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease
medicine
-
RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease
medicine
enzyme RetSat is a critical regulator of liver metabolism functioning upstream of ChREBP. Pharmacological inhibition of liver RetSat may represent a therapeutic approach for steatosis
-
conserved function but altered specificity of RetSat in vertebrates
additional information
-
conserved function but altered specificity of RetSat in vertebrates
additional information
conserved function but altered specificity of RetSat in vertebrates