1.3.99.23: all-trans-retinol 13,14-reductase
This is an abbreviated version!
For detailed information about all-trans-retinol 13,14-reductase, go to the full flat file.
Word Map on EC 1.3.99.23
Reaction
Synonyms
(13,14)-all-trans-retinol saturase, 13,14-dihydroretinol saturase, all-trans-13,14-dihydroretinol saturase, all-trans-retinol:all-trans-13,14-dihydroretinol saturase, rat mammary tumor 7, retinol saturase, RetSat, RetSat A, Rmt7
ECTree
1.3.99.23 all-trans-retinol 13,14-reductaseAdvanced search results
results (
results (Results
in table
4
111
25
18
39
Engineering
Engineering on EC 1.3.99.23 - all-trans-retinol 13,14-reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
E34A
-
mutant, mutation within the highly conserved region of the dinucleotide-binding motif
E96A
-
mutant, mutation within the highly conserved region of the dinucleotide-binding motif
E34A
-
mutant, mutation within the highly conserved region of the dinucleotide-binding motif
E96A
-
mutant, mutation within the highly conserved region of the dinucleotide-binding motif
additional information
additional information
-
generation of RetSat-/- mice, phenotype in comparison to wild-type mice, overview
additional information
mice with germline deletion of Retsat show no differences in hepatic triglycerides, cholesterol, phospholipids, or non-esterified fatty acids (NEFAs) when analyzed on a mixed 129Sv/C57BL/6 background. When backcrossed to C57BL/6N, hepatic triglycerides are increased, irrespective of feeding normal chow or HFD, whereas the abundance of many polar unsaturated lipid species is decreased. Although showing increased body weight, the whole-body and liver-specific insulin sensitivity of RetSat-deficient mice is not impaired. In contrast to these results are findings from adult C57BL/6J mice with acute liver-specific RetSat depletion. When fed normal chow, liver-specific RetSat knockdown does not induce major abnormalities. But when fed on a HFD, these mice accumulate fewer triglycerides in liver and show lower levels of triglycerides and NEFAs in the circulation. Moreover, blood glucose and insulin levels are reduced, in conjunction with increased glucose tolerance but comparable insulin sensitivity. Mechanistically, this is associated with decreased mRNA, protein, and target gene expression of carbohydrate response element-binding protein (ChREBP)
additional information
mouse hepatocytes and 3T3-L1 adipocytes are depleted of RetSat by siRNA for 48 h, phenotype, detailed overview
additional information
-
mouse hepatocytes and 3T3-L1 adipocytes are depleted of RetSat by siRNA for 48 h, phenotype, detailed overview
-
