220.127.116.11: cypemycin cysteine dehydrogenase (decarboxylating)
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CYPD, cypemycin decarboxylase, cypemycin dehydratase.
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Systematic Name on EC 18.104.22.168 - cypemycin cysteine dehydrogenase (decarboxylating)
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cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys:acceptor oxidoreductase (decarboxylating, cyclizing)
Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.