1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating)

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For detailed information about cypemycin cysteine dehydrogenase (decarboxylating), go to the full flat file.

Reaction

Synonyms

CYPD, cypemycin decarboxylase, cypemycin dehydratase.

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.99 With unknown physiological acceptors

                1.3.99.36 cypemycin cysteine dehydrogenase (decarboxylating)

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Results

in table

3

AA Sequence

2

Cloned(Commentary)

5

Cofactor

1

Crystallization (Commentary)

16

General Information

8

Natural Substrates/ Products (Substrates)

23

Organism

1

PDB ID

1

pH Optimum

2

Protein Variants

2

Purification (Commentary)

1

Reaction

10

Reference

12

Substrates and Products (Substrate)

4

Subunits

16

Synonyms

1

Systematic Name

1

Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.3.99.36 - cypemycin cysteine dehydrogenase (decarboxylating)

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SYSTEMATIC NAME

IUBMB Comments

cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys:acceptor oxidoreductase (decarboxylating, cyclizing)

Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.