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1.3.99.5: 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor), go to the full flat file.

Word Map on EC 1.3.99.5

Reaction

a 3-oxo-5alpha-steroid
+
acceptor
=
a 3-oxo-DELTA4-steroid
 +
reduced acceptor

Synonyms

3-keto-DELTA4-steroid-5 alpha-reductase, 3-ketosteroid-DELTA4(5alpha)-dehydrogenase, 3-oxo-5alpha-steroid DELTA4-dehydrogenase, 3-oxo-steroid-4-ene dehydrogenase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-ketosteroid-5alpha-oxidoreductase, 5 alpha-SR2, 5-alpha reductase II, 5alpha reductase, 5alpha-R, 5alpha-R1, 5alpha-reductase, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-reductase type1, 5alpha-reductase type2, 5alphaR1, 5alphaR2, 5AR2, dehydrogenase, 3-oxo-5alphasteroid DELTA4-, DELTA4(5alpha)DH, DELTA4-3-keto steroid 5alpha-reductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-oxo steroid reductase, DELTA4-3-oxosteroid-5alpha-reductase, DELTA4-5alpha-dehydrogenase, NADPH-dependent 5alpha-reductase enzyme, r5alphaR1, S5alphaRI, S5alphaRII, S5AR, SRD5A1, SRD5A2, SRD5alpha, steroid 5-alpha reductase type 2, steroid 5-alpha-reductase type 2, steroid 5alpha-reductase, steroid 5alpha-reductase type 1, steroid 5alpha-reductase type 2, steroid DELTA4-5alpha-reductase, steroid-5alpha-reductase, testosterone 5alpha-reductase, type 1 5alpha-reductase, type 2 5alpha-reductase, type I 5alpha-reductase, type II 5alpha-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

Reference

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Reference on EC 1.3.99.5 - 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Levy, H.R.; Talalay, P.
Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation
J. Biol. Chem.
234
2014-2021
1959
Comamonas testosteroni
Manually annotated by BRENDA team
Farkash, Y.; Soreq, H.; Orly, J.
Biosynthesis of catalytically active rat testosterone 5alpha-reductase in microinjected Xenopus oocytes: evidence for tissue-specific differences in translatable mRNA
Proc. Natl. Acad. Sci. USA
85
5824-5828
1988
Rattus norvegicus
Manually annotated by BRENDA team
Florin, C.; Koehler, T.; Grandguillot, M.; Plesiat, P.
Comamonas testosteroni 3-ketosteroid-DELTA4(5alpha)-dehydrogenase
J. Bacteriol.
178
3322-3330
1996
Comamonas testosteroni
Manually annotated by BRENDA team
Torres, J.M.; Ortega, E.
Precise quantitation of steroid 5alpha-reductase type 1 mRNA levels by RT-PCR in female rat liver
Endocr. Res.
30
149-157
2004
Rattus norvegicus
Manually annotated by BRENDA team
Torres, J.M.; Ortega, E.
Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain
FASEB J.
17
1428-1433
2003
Rattus norvegicus
Manually annotated by BRENDA team
Torres, J.M.; Ortega, E.
Quantitation of mRNA levels of steroid 5alpha-reductase isozymes: a novel method that combines quantitative RT-PCR and capillary electrophoresis
Int. J. Biochem. Cell Biol.
36
78-88
2004
Rattus norvegicus
Manually annotated by BRENDA team
Woelfling, J.; Hackler, L.; Mernyak, E.; Schneider, G.; Toth, I.; Szecsi, M.; Julesz, J.; Sohar, P.; Csampai, A.
Neighboring group participation. Part 15. Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones, as novel presumed inhibitors of human 5alpha-reductase
Steroids
69
451-460
2004
Homo sapiens
Manually annotated by BRENDA team
Luu-The, V.; Pelletier, G.; Labrie, F.
Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase
J. Steroid Biochem. Mol. Biol.
93
269-276
2005
Mus musculus
Manually annotated by BRENDA team
Park Jun-Seon, P.J.; Yeom Myeong-Hoo, Y.M.; Park Won-Seo, P.W.; Joo Kyung-M, J.K.; Rho Ho-Si, R.H.; Kim Duck He, K.D.; Chang Ih Seo, C.I.
Enzymatic hydrolysis of green tea seed extract and its activity on 5alpha-reductase inhibition
Biosci. Biotechnol. Biochem.
70
387-394
2006
Homo sapiens
Manually annotated by BRENDA team
Titus, M.A.; Gregory, C.W.; Ford, O.H.; Schell, M.J.; Maygarden, S.J.; Mohler, J.L.
Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancer
Clin. Cancer Res.
11
4365-4371
2005
Homo sapiens
Manually annotated by BRENDA team
Skalba, P.; Dabkowska-Huc, A.; Kazimierczak, W.; Samojedny, A.; Samojedny, M.P.; Chelmicki, Z.
Content of 5-alpha-reductase (type 1 and type 2) mRNA in dermal papillae from the lower abdominal region in women with hirsutism
Clin. Exp. Dermatol.
31
564-570
2006
Homo sapiens
Manually annotated by BRENDA team
Kim Sung Hoo, K.S.; Kim Kun Su, K.K.; Kim Gu Hwa, K.G.; Kang Byung Moo, K.B.; Yoo Han Woo, Y.H.
A novel frameshift mutation in the 5alpha-reductase type 2 gene in Korean sisters with male pseudohermaphroditism
Fertil. Steril.
85(750)
e9-e12
2006
Homo sapiens
Manually annotated by BRENDA team
Elzanaty, S.; Giwercman, Y.L.; Giwercman, A.
Significant impact of 5alpha-reductase type 2 polymorphisms on sperm concentration and motility
Int. J. Androl.
29
414-420
2006
Homo sapiens
Manually annotated by BRENDA team
Festuccia, C.; Angelucci, A.; Gravina, G.L.; Muzi, P.; Vicentini, C.; Bologna, M.
Effects of 5 alpha reductase inhibitors on androgen-dependent human prostatic carcinoma cells
J. Cancer Res. Clin. Oncol.
131
243-254
2005
Homo sapiens
Manually annotated by BRENDA team
Salem, O.I.; Frotscher, M.; Scherer, C.; Neugebauer, A.; Biemel, K.; Streiber, M.; Maas, R.; Hartmann, R.W.
Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids
J. Med. Chem.
49
748-759
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lou, Y.R.; Murtola, T.; Tuohimaa, P.
Regulation of aromatase and 5alpha-reductase by 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3), dexamethasone and progesterone in prostate cancer cells
J. Steroid Biochem. Mol. Biol.
94
151-157
2005
Homo sapiens
Manually annotated by BRENDA team
Robaire, B.; Henderson, N.A.
Actions of 5alpha-reductase inhibitors on the epididymis
Mol. Cell. Endocrinol.
250
190-195
2006
Rattus norvegicus
Manually annotated by BRENDA team
Agis-Balboa, R.C.; Pinna, G.; Zhubi, A.; Maloku, E.; Veldic, M.; Costa, E.; Guidotti, A.
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
Proc. Natl. Acad. Sci. USA
103
14602-14607
2006
Mus musculus
Manually annotated by BRENDA team
Gleave, M.; Qian, J.; Andreou, C.; Pommerville, P.; Chin, J.; Casey, R.; Steinhoff, G.; Fleshner, N.; Bostwick, D.; Thomas, L.; Rittmaster, R.
The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer - results from a 4-month pre-radical prostatectomy study
Prostate
66
1674-1685
2006
Homo sapiens
Manually annotated by BRENDA team
Lu, Y.L.; Kuang, L.; Zhu, H.; Wu, H.; Wang, X.F.; Pang, Y.P.; Wang, N.J.; Yu, D.L.
Changes in aortic endothelium ultrastructure in male rats following castration, replacement with testosterone and administration of 5alpha-reductase inhibitor
Asian J. Androl.
9
843-847
2007
Rattus norvegicus
Manually annotated by BRENDA team
Verdi, J.; Ahmadiani, A.
Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat
Horm. Behav.
51
605-610
2007
Rattus norvegicus
Manually annotated by BRENDA team
Baldinotti, F.; Majore, S.; Fogli, A.; Marrocco, G.; Ghirri, P.; Vuerich, M.; Tumini, S.; Boscherini, B.; Vetri, M.; Scommegna, S.; Rinaldi, R.; Simi, P.; Grammatico, P.
Molecular characterization of 6 unrelated Italian patients with 5alpha-reductase type 2 deficiency
J. Androl.
29
20-28
2008
Homo sapiens
Manually annotated by BRENDA team
Amory, J.K.; Anawalt, B.D.; Matsumoto, A.M.; Page, S.T.; Bremner, W.J.; Wang, C.; Swerdloff, R.S.; Clark, R.V.
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men
J. Urol.
179
2333-2338
2008
Homo sapiens
Manually annotated by BRENDA team
Szécsi, M.; Ondré, D.; Tóth, I.; Magony, S.; Wölfling, J.; Schneider, G.; Julesz, J.
Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
Acta Biol. Hung.
61
274-281
2010
Rattus norvegicus
Manually annotated by BRENDA team
Paz-y-Min, C.; Witte, T.; Robles, P.; Llumipanta, W.; Diaz, M.; Arevalo, M.
Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population
Cancer Genet. Cytogenet.
189
71-76
2009
Homo sapiens (P31213), Homo sapiens
Manually annotated by BRENDA team
Li, Y.H.; Yang, Y.F.; Li, K.; Jin, L.L.; Yang, N.Y.; Kong, D.Y.
5 alpha-reductase and aromatase inhibitory constituents from Brassica rapa L. pollen
Chem. Pharm. Bull.
57
401-404
2009
Rattus norvegicus
Manually annotated by BRENDA team
Seo, Y.-K.; Zhu, B.; Jeon, T.-I.; Osborne, T.F.
Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
Exp. Cell Res.
315
3133-3139
2009
Mus musculus
Manually annotated by BRENDA team
Cohen, R.E.; Wade, J.
Testosterone selectively affects aromatase and 5alpha-reductase activities in the green anole lizard brain
Gen. Comp. Endocrinol.
166
128-133
2010
Anolis carolinensis
Manually annotated by BRENDA team
Ramos, L.; Chavez, B.; Vilchis, F.
Cloning and differential expression of steroid 5alpha-reductase type 1 (Srd5a1) and type 2 (Srd5a2) from the Harderian glands of hamsters
Gen. Comp. Endocrinol.
166
388-395
2010
Mesocricetus auratus (C7T2J7), Mesocricetus auratus (C7T2J8)
Manually annotated by BRENDA team
Langlois, V.S.; Zhang; D.; Cooke, G.M.; Trudeau, V.L.
Evolution of steroid-5alpha-reductases and comparison of their function with 5beta-reductase
Gen. Comp. Endocrinol.
166
489-497
2010
Danio rerio, Canis lupus familiaris, Gallus gallus, Mus musculus, Rattus norvegicus, Xenopus tropicalis, Homo sapiens (P31213)
Manually annotated by BRENDA team
Ko, J.M.; Cheon, C.-K.; Kim, G.-H.; Kim, S.H.; Kim, K.S.; Yoo, H.-W.
Clinical characterization and analysis of the SRD5A2 gene in six Korean patients with 5alpha-reductase type 2 deficiency
Horm. Res. Paediatr.
73
41-48
2010
Homo sapiens (P31213), Homo sapiens
Manually annotated by BRENDA team
Tóth, I.; Szécsi, M.; Julesz, J.; Faredin, I.; Behnke, B.
In vitro inhibition of testicular delta 5-3 beta-hydroxysteroid dehydrogenase and prostatic 5 alpha-reductase activities in rats and humans by strogen forte extract
Int. Urol. Nephrol.
28
337-348
1996
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kim, S.; Ma, E.
Synthesis of pregnane derivatives, their cytotoxicity on LNCap and PC-3 cells, and screening on 5alpha-reductase inhibitory activity
Molecules
14
4655-4668
2009
Homo sapiens
Manually annotated by BRENDA team
Thomas, L.N.; Douglas, R.C.; Rittmaster, R.S.; Too, C.K.L.
Overexpression of 5alpha-reductase type1 increases sensitivity of prostate cancer cells to low concentrations of testosterone
Prostate
69
595-602
2009
Homo sapiens (P18405), Homo sapiens (P31213)
Manually annotated by BRENDA team
Gupta, S.; Wang, Y.; Ramos-Garcia, R.; Shevrin, D.; Nelson, J.B.; Wang, Z.
Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice
Prostate
70
1575-1585
2010
Homo sapiens
Manually annotated by BRENDA team
Aggarwal, S.; Thareja, S.; Verma, A.; Bhardwaj, T.R.; Kumar, M.
An overview on 5alpha-reductase inhibitors
Steroids
75
109-153
2010
Rattus norvegicus, Homo sapiens (P18405), Homo sapiens (P31213), Homo sapiens
Manually annotated by BRENDA team
Aggarwal, S.; Thareja, S.; Bhardwaj, T.R.; Kumar, M.
Self-organizing molecular field analysis on pregnane derivatives as human steroidal 5alpha-reductase inhibitors
Steroids
75
411-418
2010
Homo sapiens
Manually annotated by BRENDA team
van Oosterwijk, N.; Knol, J.; Dijkhuizen, L.; van der Geize, R.; Dijkstra, B.W.
Structure and catalytic mechanism of 3-ketosteroid-DELTA4-(5alpha)-dehydrogenase from Rhodococcus jostii RHA1 genome
J. Biol. Chem.
287
30975-30983
2012
Rhodococcus jostii (Q0S4Q9)
Manually annotated by BRENDA team
Park, J.S.; Yeom, M.H.; Park, W.S.; Joo, K.M.; Rho, H.S.; Kim, D.H.; Chang, I.S.
Enzymatic hydrolysis of green tea seed extract and its activity on 5alpha-reductase inhibition
Biosci. Biotechnol. Biochem.
70
387-94
2006
Homo sapiens
Manually annotated by BRENDA team
Kim, J.; Lee, J.; Yoon, H.; Kim, Y.; Jun, W.; Hwang, K.; Cha, M.; Lee, Y.
Inhibitory effect of curcuma longa L. extracts on 5-alpha reductase II activity
J. Korean Soc. Food Sci. Nutr.
43
318-322
2014
Homo sapiens, Rattus norvegicus
-
Manually annotated by BRENDA team
Li, Q.; Zhu, Y.; He, J.; Wang, M.; Zhu, M.; Shi, T.; Qiu, L.; Ye, D.; Wei, Q.
Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis
Mol. Biol. Rep.
40
3597-3608
2013
Homo sapiens
Manually annotated by BRENDA team