Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.3.99.6: 3-oxo-5beta-steroid 4-dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxo-5beta-steroid 4-dehydrogenase, go to the full flat file.

Word Map on EC 1.3.99.6

Reaction

a 3-oxo-5beta-steroid
+
acceptor
=
a 3-oxo-DELTA4-steroid
+
reduced acceptor

Synonyms

3-keto-DELTA4-steroid-5beta-reductase, 3-oxo-5beta-steroid DELTA4-dehydrogenase, 3-oxo-DELTA4-steroid-5beta-reductase, 5beta-reductase, AKR1D1, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, DELTA-3-ketosteroid-5beta-reductase, DELTA4-3-ketosteroid-5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-5beta-DH, steroid 5beta reductase, steroid 5beta-reductase, steroid DELTA-5beta-dehydrogenase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.6 3-oxo-5beta-steroid 4-dehydrogenase

Reference

Reference on EC 1.3.99.6 - 3-oxo-5beta-steroid 4-dehydrogenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stokes, N.A.; Hylemon, P.B.
Characterization of DELTA4-3-ketosteroid-5beta-reductase and 3beta-hydroxysteroid dehydrogenase in cell extracts of Clostridium innocuum
Biochim. Biophys. Acta
836
255-261
1985
[Clostridium] innocuum, Clostridium paraputrificum
Manually annotated by BRENDA team
Gao, X.; Liu, J.; Li, G.
Purification and properties of 3alpha-hydroxysteroid dehydrogenase and 3-keto-5beta-steroid-DELTA4-dehydrogenase
Ann. N. Y. Acad. Sci.
864
383-392
1998
Pseudomonas sp.
Manually annotated by BRENDA team
Aries, V.C.; Goddard, P.; Hill, M.J.
Degradation of steroids by intestinal bacteria. III. 3-Oxo-5beta-steroid DELTA1-dehydrogenase and 3-oxo-5beta-steroid DELTA4-dehydrogenase
Biochim. Biophys. Acta
248
482-488
1971
Clostridium paraputrificum
-
Manually annotated by BRENDA team
Davidson, S.J.; Talalay, P.
Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase
J. Biol. Chem.
241
906-915
1966
Comamonas testosteroni
Manually annotated by BRENDA team
Zhu, Y.; Fillienwarth, M.J.; Crabb, D.; Lumeng, L.; Lin, R.C.
Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as DELTA4-3-ketosteroid 5beta-reductase
Hepatology
23
115-122
1996
Rattus norvegicus
Manually annotated by BRENDA team
Ando, Y.; Ide, H.; Kosai, S.; Kamimura, R.; Maeda, Y.; Higashi, S.; Setoguchi, T.
Expression of cholesterol 7alpha-hydroxylase and DELTA4-3-ketosteroid 5beta-reductase genes in rat pancreatic hepatocyte-like cells
J. Lipid Res.
40
1793-1798
1999
Rattus norvegicus
Manually annotated by BRENDA team
Lemonde, H.A.; Custard, E.J.; Bouquet, J.; Duran, M.; Overmars, H.; Scambler, P.J.; Clayton, P.T.
Mutations in SRD5B1 (AKR1D1), the gene encoding DELTA4-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy
Gut
52
1494-1499
2003
Homo sapiens
Manually annotated by BRENDA team
Sheenan, P.M.; Rice, G.E.; Moses, E.K.; Brennecke, S.P.
5beta-Dihydroprogesterone and steroid 5beta-reductase decrease in association with human parturition at term
Mol. Hum. Reprod.
11
495-501
2005
Homo sapiens
Manually annotated by BRENDA team