1.3.99.8: 2-furoyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about 2-furoyl-CoA dehydrogenase, go to the full flat file.

Reaction

2-Furoyl-CoA
+
H2O
+
acceptor
=
S-(5-Hydroxy-2-furoyl)-CoA
+
reduced acceptor

Synonyms

2-furoyl coenzyme A dehydrogenase, 2-furoyl coenzyme A hydroxylase, dehydrogenase, 2-furoyl coenzyme A, furoyl-CoA hydroxylase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.8 2-furoyl-CoA dehydrogenase

Systematic Name

Systematic Name on EC 1.3.99.8 - 2-furoyl-CoA dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)
A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.