1.4.1.13: glutamate synthase (NADPH)

This is an abbreviated version!
For detailed information about glutamate synthase (NADPH), go to the full flat file.

Word Map on EC 1.4.1.13

Reaction

2 L-glutamate +

NADP+
=
L-glutamine
+
2-oxoglutarate
+
NADPH
+
H+

Synonyms

EC 2.6.1.53, EhNO1, EhNO2, gltA, gltB, GltB1, GltB2, gltD, GltS, glutamate synthetase (NADP), glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP), glutamine-ketoglutaric aminotransferase, GOGAT, L-glutamate synthase, L-glutamate synthetase, L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing, NADPH-dependent glutamate synthase, NADPH-GltS, NADPH-glutamate synthase, NADPH-GOGAT, NADPH-linked glutamate synthase, pGLTY1, pGLTY2, pGLTZ, PH0876, PH1873, synthase, glutamate (reduced nicotinamide adenine dinucleotide phosphate)

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.13 glutamate synthase (NADPH)

Inhibitors

Inhibitors on EC 1.4.1.13 - glutamate synthase (NADPH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2',5'-ADP
-
act as a competitive ihibitor
2',5'-diphosphoadenylic acid
-
competitive inhibitor with respect to NADPH
2'-adenylic acid
2'-phosphoadenosine-5'-diphospho-5'-beta-D-ribose
2'-phosphoadenylic acid
-
competitive inhibitor with respect to NADPH
2,2'-bipyridyl
3-Aminopyridine adenine dinucleotide phosphate
3-Bromo-2-oxoglutarate
-
-
4-Iodoacetamidosalicylate
6-diazo-5-oxo-L-norleucine
acetyl-NADP+
-
-
AgNO3
-
at 0.001 mM completely inhibits
alpha-aminobutyrate
-
-
arginine
-
less than 45% inhibition
Atebrin
-
100% inhibition at 1 mM
azaserine
BaCl2
-
61% inhibition at 50 mM
Bromopyruvate
-
-
Butane-2,3-dione
-
slight inactivation
CaCl2
CdCl2
-
produces more than 60% inhibition at 5 mM
Cibacron blue 3GA
-
-
cis-aconitate
-
22% inhibition at 50 mM
citrate
-
slight
CoCl2
-
produces more than 60% inhibition at 5 mM
CTP
-
9% inhibition at 25 mM and 21% inhibition at 50 mM
D-glutamate
D-glutamine
-
-
D-Lysine
-
significantly inhibits
D-methionine
-
19% inhibition at 50 mM
dimethyl suberimidate
-
inactivates glutamine-dependent activity
DL-methionine DL-sulfoximine
DL-methionine sulfoxide
-
potent inhibitor
DL-Theanine
-
-
fumarate
glycine
GTP
-
16% inhibition at 25 mM and 43% inhibition at 50 mM
HgCl2
-
at 0.001 mM remains 8% of activity
hydroxylamine
-
-
iodoacetamide
iodoacetate
iodonitrotetrazolium
-
inhibitor of the L-glutamate:iodonitrotetrazolim oxidoreductase activity of the alpha subunit at concentrations above 0.1 mM
isocitrate
ITP
-
17% inhibition at 25 mM and 29% inhibition at 50 mM
KCl
-
32% inhibition at 100 mM
KCN
-
89% inhibition at 20 mM
KNO3
-
47% inhibition at 100 mM
L-2-Amino-4-oxo-5-chloropentanoic acid
L-alanine
L-asparagine
L-aspartate
L-cysteine
-
significant inhibitor
L-glutamate
L-histidine
L-homoserine
L-leucine
L-malate
L-methionine
L-methionine DL-sulfoximine
L-Methionine sulfone
L-MetS
-
reversible inhibitor
L-serine
L-tryptophan
-
strong inhibitor
lysine
methionine sulfone
-
-
MgCl2
MnCl2
N-ethylmaleimide
NAD+
-
competitive inhibition with NADH, noncompetitive inhibition with 2-oxoglutarate or L-glutamine
NADPH
NaN3
-
100% inhibition at 50 mM, 11% inhibition at 20 mM
NiCl2
-
produces more than 60% inhibition at 5 mM
O-carbamoylserine
-
competitive inhibitor vs. L-glutamine
o-phenanthroline
oxalate
-
48% inhibition at 5 mM
oxalglycine
-
-
oxaloacetate
oxalylglycine
-
competitive inhibitor vs. alpha-ketoglutarate, noncompetitive inhibitor vs. L-glutamine and uncompetitive vs. NADPH
p-chloromercuribenzoate
p-chloromercuriphenylsulfonate
-
more than 50% loss in activity in 60 min at 0.05 mM
p-hydroxymercuribenzoate
-
complete inhibition at 1 mM, 5 min
phenylalanine
Phenylglyoxal
-
at 3 mM pyridoxal 5'-phosphate glutamine-dependent glutamate synthase is inactivated by about 50% within 10 min. This inactivation is not prevented by 2-oxoglutarate
putrescine
-
-
pyridoxal-5'-phosphate
-
52% inhibition of the glutamine-dependent reaction at 5 mM
pyruvate
Sodium arsenite
succinate
UTP
-
17% inhibition at 25 mM and 33% inhibition at 50 mM
valine
additional information
-