1.4.1.16: diaminopimelate dehydrogenase

This is an abbreviated version!
For detailed information about diaminopimelate dehydrogenase, go to the full flat file.

Reaction

Synonyms

BAB07799, BF3690, DAPDH, DDH, meso-2,6-diaminopimelate dehydrogenase, meso-alpha,epsilon-diaminopimelate dehydrogenase, meso-DAPDH, meso-diaminopimelate dehydrogenase, NADP+-dependent meso-diaminopimelate dehydrogenase, Sth1425, Theth_1310

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.16 diaminopimelate dehydrogenase

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Results	in table
3529	AA Sequence
4	Application
1	CAS Registry Number
20	Cloned(Commentary)
84	Cofactor
8	Crystallization (Commentary)
4	General Information
5	IC50 Value
77	Inhibitors
77	kcat/KM [mM/s]
10	Ki Value [mM]
133	KM Value [mM]
1	Metals/Ions
15	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
120	Organism
6	Pathway
38	PDB ID
21	pH Optimum
3	pH Range
4	pH Stability
52	Protein Variants
18	Purification (Commentary)
5	Reaction
3	Reaction Type
111	Reference
34	Specific Activity [micromol/min/mg]
5	Storage Stability
211	Substrates and Products (Substrate)
17	Subunits
42	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
12	Temperature Stability [°C]
102	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.4.1.16 - diaminopimelate dehydrogenase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

apo form and in complex with meso-diaminopimelate, D-leucine, and 4-methyl-2-oxopentanoic acid, sitting drop vapor diffusion method, using MES (0.1 M, pH 6.0), 15% (w/v) PEG 20000, and 5% (v/v) glycerol

Clostridium tetani

Q890V3

742282

crystallization in the presence of NADP+, only monoclinic crystals are suitable for X-ray diffraction, 2.2 A resolution

Corynebacterium glutamicum

P04964

391520

crystals of the ternary complex formed from the enzyme, NADP+ and the inhibitor (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid

Corynebacterium glutamicum

P04964

391523

crystals of the ternary complex formed from the enzyme, NADP+ and the inhibitor L-2-amino-6-methylene-pimelate, 2.1 A resolution

Corynebacterium glutamicum

-

391524

enzyme-NADP+ complex, hanging drop vapour diffusion, crystals of maximum dimensions of 0.05 x 0.05 x 0.5 mm are observed in 1 M ammonium sulfate, 1.2 M lithium sulfate, 100 mM HEPES, pH 7.5, crystals of dimensions 0.3 x 0.05 x 0.5 mm are obtained from 13-17% polyethylene glycol 8000 in 100 mM sodium cacodylate, pH 6.5 and 150-300 mM Mg(OAc)2

Corynebacterium glutamicum

-

391521

apo form and in complex with NADP+ and both NADPH and meso-2,6-diaminoheptanedioate, sitting drop vapor diffusion method, using 0.1m HEPES buffer (pH 7.5) with 30% 2-methyl-2,4-pentanediol and 5% (v/v) glycerol

Symbiobacterium thermophilum

Q67PI3

742276

molecular docking of substrates meso-DAP and pyruvic acid to wild-type and mutant R71A. Substrate binding with meso-DAP or pyruvic acid changes the rigidity of the enzyme and the secondary structure around R71

Symbiobacterium thermophilum

Q67PI3

762982

apo form and in complex with NADP+ and N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, sitting drop vapor diffusion method, using 1.9 M ammonium sulfate,0.1 M Tris-HCl pH 7.5

Ureibacillus thermosphaericus

G1UII1

741514