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1.4.1.16: diaminopimelate dehydrogenase

This is an abbreviated version!
For detailed information about diaminopimelate dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.16

Reaction

meso-2,6-diaminoheptanedioate
+
H2O
 +
NADP+
=
L-2-amino-6-oxoheptanedioate
 +
NH3
 +
NADPH
 +
H+

Synonyms

BAB07799, BF3690, DAPDH, DDH, meso-2,6-diaminopimelate dehydrogenase, meso-alpha,epsilon-diaminopimelate dehydrogenase, meso-DAPDH, meso-diaminopimelate dehydrogenase, NADP+-dependent meso-diaminopimelate dehydrogenase, Sth1425, Theth_1310

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.16 diaminopimelate dehydrogenase

Specific Activity

Specific Activity on EC 1.4.1.16 - diaminopimelate dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.013
-
activity in crude extracts at pH 8.0
0.022
with 4-methyl-2-oxopentanoic acid as substrate, at pH 9.0 and 30°C
0.03
-
reductive amination of 2-amino-6-oxopimelate in crude extracts at pH 7.5 in the presence of 1.67 mM meso-diaminopimelate
0.07
recombinant wild-type enzyme, pH 8.5, 30°C
0.12
-
activity in crude extracts
0.13
-
strain AS019 transformed with plasmid harboring cloned gene
0.16
-
activity in strain RRL-5
0.219
with pyruvate as substrate, at pH 9.0 and 30°C
0.237
-
reductive amination of 2-amino-6-oxopimelate in crude extracts at pH 7.5
0.25
-
reductive amination of 2-amino-6-oxopimelate in crude extracts at pH 7.5
0.28
recombinant mutant T171S/R181F, pH 8.5, 30°C
0.287
-
oxidative deamination of meso-diaminopimelate in crude extracts at pH 10.5
0.34
-
activity in crude extracts at pH 10.5
0.44
recombinant mutant R181F, pH 8.5, 30°C
0.45
-
oxidative deamination of meso-diaminopimelate in crude extracts at pH 10.5
0.53
-
activity in crude extracts
0.74
recombinant mutant T171S/H227V, pH 8.5, 30°C
1.02
recombinant mutant T171S/R181F/H227V, pH 8.5, 30°C
1.03
recombinant mutant H227C, pH 8.5, 30°C
1.036
with meso-2,6-diaminoheptanedioate as substrate, at pH 9.5 and 30°C
1.35
recombinant mutant R181F/H227V, pH 8.5, 30°C
2.22
-
activity in strain RRL-5 transformed with plasmid harboring cloned gene
2.39
recombinant mutant H227V, pH 8.5, 30°C
701
-
pH 10.5, temperature not specified in the publication
8.28
-
purified enzyme, pH 7.2, 50°C