1.4.1.19: tryptophan dehydrogenase

This is an abbreviated version!
For detailed information about tryptophan dehydrogenase, go to the full flat file.

Reaction

L-tryptophan

+

NAD(P)+

+

H2O

=

(indol-3-yl)pyruvate

+

NH3

+

NAD(P)H

+

H+

Synonyms

dehydrogenase, tryptophan, L-Trp dehydrogenase, L-Trp-dehydrogenase, L-tryptophan dehydrogenase, NAD(P)-L-tryptophan dehydrogenase, NAD+-dependent L-tryptophan dehydrogenase, TDH, TrpDH

ECTree

1 Oxidoreductases

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.1.19 tryptophan dehydrogenase

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Results	in table
1	Activating Compound
23	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
23	Cofactor
1	Crystallization (Commentary)
3	Inhibitors
19	kcat/KM [mM/s]
1	Ki Value [mM]
28	KM Value [mM]
3	Localization
5	Metals/Ions
1	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
18	Organism
6	PDB ID
3	pH Optimum
1	pH Stability
29	Protein Variants
3	Purification (Commentary)
1	Reaction
5	Reaction Type
18	Reference
14	Source Tissue
22	Specific Activity [micromol/min/mg]
31	Substrates and Products (Substrate)
6	Subunits
17	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
19	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.4.1.19 - tryptophan dehydrogenase

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0.014

Spinacia oleracea

-

activity in organelles, cofactor NAD+, deamination of L-tryptophan

0.0155

Spinacia oleracea

-

activity in organelles, cofactor NADP+, deamination of L-tryptophan

0.0359

Spinacia oleracea

-

activity in organelles, cofactor NADH, amination of L-tryptophan

0.648

Spinacia oleracea

-

activity in organelles, cofactor NADPH, amination of L-tryptophan

0.87

Nicotiana tabacum

-

cofactor NADH, activity in normal BV-N strain

1.22

Nicotiana tabacum

-

cofactor NADPH, activity in normal BV-N strain

1.24

Nicotiana tabacum

-

cofactor NADH or NADPH, activity in tumor tobacco tissue strains T-24

1.57

Nicotiana tabacum

-

cofactor NADH, activity in tumor tobacco tissue strain C-58

1.59

Nicotiana tabacum

-

cofactor NADPH, activity in tumor tobacco tissue strain C-58

14

-

activity in the apical part of the epicotyl in five-day-old etiolated seedlings 48 h after root excision

18

-

activity in the apical part of the epicotyl in five-day-old etiolated seedlings immidiately after root excision

22

Prosopis juliflora

-

activity in roots, cofactor NADH

23

-

activity in the apical part of the epicotyl in five-day-old etiolated seedlings 12 h after root excision

28

Solanum lycopersicum

-

activity in shoots, cofactor NADH

30

Prosopis juliflora

-

activity in roots, cofactor NADPH

39

Solanum lycopersicum

-

activity in shoots, cofactor NADPH

45

-

activity in shoots, cofactor NADH

52

-

activity in shoots, cofactor NADH

6

Prosopis juliflora

-

activity in shoots, cofactor NADH

64

-

activity in shoots, cofactor NADPH

70

-

activity in shoots, cofactor NADPH

9

Prosopis juliflora

-

activity in shoots, cofactor NADPH

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Release 2023.1 (January 2023)