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1.4.1.21: aspartate dehydrogenase

This is an abbreviated version!
For detailed information about aspartate dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.21

Reaction

2-iminosuccinate
+
H2O
=
oxaloacetate
+
NH3

Synonyms

AspDH, L-aspartate dehydrogenase, L-aspartate:NAD(P)+ oxidoreductase (deaminating), L-aspDH, NAD-dependent aspartate dehydrogenase, NADH2-dependent aspartate dehydrogenase, NADP+-dependent aspartate dehydrogenase, nadX

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.21 aspartate dehydrogenase

Reference

Reference on EC 1.4.1.21 - aspartate dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okamura, T.; Noda, H.; Fukuda, S.; Ohsugi, M.
Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541
J. Nutr. Sci. Vitaminol.
44
483-490
1998
Klebsiella pneumoniae
Manually annotated by BRENDA team
Kretovich, W.L.; Kariakina, T.I.; Weinova, M.K.; Sidelnikova, L.I.; Kazakova, O.W.
The synthesis of aspartic acid in Rhizobium lupini bacteroids
Plant Soil
61
145-156
1981
Bradyrhizobium lupini, Bradyrhizobium lupini 359a
-
Manually annotated by BRENDA team
Yang, Z.; Savchenko, A.; Yakunin, A.; Zhang, R.; Edwards, A.; Arrowsmith, C.; Tong, L.
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643
J. Biol. Chem.
278
8804-8808
2003
Thermotoga maritima (Q9X1X6), Thermotoga maritima
Manually annotated by BRENDA team
Yoneda, K.; Kawakami, R.; Tagashira, Y.; Sakuraba, H.; Goda, S.; Ohshima, T.
The first archaeal L-aspartate dehydrogenase from the hyperthermophile Archaeoglobus fulgidus: Gene cloning and enzymological characterization
Biochim. Biophys. Acta
1764
1087-1093
2006
Archaeoglobus fulgidus
Manually annotated by BRENDA team
Yoneda, K.; Sakuraba, H.; Tsuge, H.; Katunuma, N.; Ohshima, T.
Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex
FEBS J.
274
4315-4325
2007
Archaeoglobus fulgidus (O28440), Archaeoglobus fulgidus, Thermotoga maritima (Q9X1X6), Thermotoga maritima
Manually annotated by BRENDA team
Kuvaeva, T.; Katashkina, J.; Kivero, A.; Smirnov, S.
Novel NADPH-dependent L-aspartate dehydrogenases from the mesophilic nitrogen-fixing bacteria Rhodopseudomonas palustris and Bradyrhizobium japonicum
Appl. Biochem. Microbiol.
49
136-143
2013
Bradyrhizobium japonicum, Rhodopseudomonas palustris
-
Manually annotated by BRENDA team
Li, Y.; Kawakami, N.; Ogola, H.J.; Ashida, H.; Ishikawa, T.; Shibata, H.; Sawa, Y.
A novel L-aspartate dehydrogenase from the mesophilic bacterium Pseudomonas aeruginosa PAO1: molecular characterization and application for L-aspartate production
Appl. Microbiol. Biotechnol.
90
1953-1962
2011
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Li, Y.; Ogola, H.J.; Sawa, Y.
L-aspartate dehydrogenase: features and applications
Appl. Microbiol. Biotechnol.
93
503-516
2012
Cupriavidus necator, Archaeoglobus fulgidus, Klebsiella pneumoniae, Thermotoga maritima, Pseudomonas aeruginosa (Q9HYA4), Klebsiella pneumoniae MGH 78578, Cupriavidus necator JMP 134-1, Klebsiella pneumoniae IFO 13541
Manually annotated by BRENDA team
Li, Y.; Ishida, M.; Ashida, H.; Ishikawa, T.; Shibata, H.; Sawa, Y.
A non-NadB type L-aspartate dehydrogenase from Ralstonia eutropha strain JMP134: molecular characterization and physiological functions
Biosci. Biotechnol. Biochem.
75
1524-1532
2011
Cupriavidus necator (Q46VA0), Cupriavidus necator JMP 134-1 (Q46VA0)
Manually annotated by BRENDA team
Ozyurt, C.; Evran, S.; Telefoncu, A.
Development of a novel fluorescent protein construct by genetically fusing green fluorescent protein to the N-terminal of aspartate dehydrogenase
Biotechnol. Appl. Biochem.
60
399-404
2013
Thermotoga maritima
Manually annotated by BRENDA team
Wu, W.; Zhang, Y.; Liu, D.; Chen, Z.
Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum
Metab. Eng.
52
77-86
2019
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Li, H.; Zhu, T.; Miao, L.; Zhang, D.; Li, Y.; Li, Q.; Li, Y.
Discovery of novel highly active and stable aspartate dehydrogenases
Sci. Rep.
7
7881
2017
Klebsiella pneumoniae, Delftia sp. Cs1-4 (F6ALN7), Klebsiella pneumoniae 34618
Manually annotated by BRENDA team