1.4.1.23: valine dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about valine dehydrogenase (NAD+), go to the full flat file.
Reaction
Synonyms
VDH, VDH2
ECTree
1.4.1.23 valine dehydrogenase (NAD+)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.4.1.23 - valine dehydrogenase (NAD+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH
-
very poor substrate: 1.2% of the activity with L-valine
pyruvate is identical with alpha-ketopropanoate and 2-oxopropanoate, reductive amination: very poor substrate, 1.3% of the activity with 2-oxoisovalerate
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NADH + NH3
-
46.5% of the activity with L-valine
2-oxo-3-methylvalerate is identical with alpha-keto-beta-methylpentanoate, reductive amination: 22.3% of the activity with 2-oxoisovalerate
r
L-leucine + H2O + NAD+
2-oxoisocaproate + NADH + NH3
-
36% of the activity with L-valine
2-oxoisocaproate is identical with 2-oxo-4-methylpentanoate, 2-oxoisohexanoate and alpha-ketoisocaproate, reductive amination: 38.1% of the activity with 2-oxoisovalerate
r
L-norleucine + H2O + NAD+
2-oxocaproate + NADH + NH3
-
10.5% of the activity with L-valine
-
-
r
2-oxobutanoate + NH3 + NADH + H+
L-2-aminobutanoate + H2O + NAD+
-
22% of the activity with 2-oxoisovalerate
-
-
r
2-oxobutanoate + NH3 + NADH + H+
L-2-aminobutanoate + H2O + NAD+
-
116% of the activity with 2-oxoisovalerate
-
-
r
2-oxobutanoate + NH3 + NADH + H+
L-2-aminobutanoate + H2O + NAD+
-
48.2% of the activity with 2-oxoisovalerate
-
-
r
2-oxobutanoate + NH3 + NADH + H+
L-2-aminobutanoate + H2O + NAD+
-
100% of the activity with 2-oxoisovalerate
-
-
r
2-oxobutanoate + NH3 + NADH + H+
L-2-aminobutanoate + H2O + NAD+
-
78% of the activity with 2-oxoisovalerate
-
-
r
2-oxobutanoate + NH3 + NADH + H+
L-2-aminobutanoate + H2O + NAD+
-
-
-
-
r
2-oxohexanoate + NH3 + NADH + H+
L-norleucine + H2O + NAD+
-
6.3% of the activity with 2-oxoisovalerate
-
-
r
2-oxohexanoate + NH3 + NADH + H+
L-norleucine + H2O + NAD+
-
43.8% of the activity with 2-oxoisovalerate
-
-
r
2-oxoisohexanoate + NH3 + NADH + H+
L-leucine + H2O + NAD+
-
58% of the activity with 2-oxoisovalerate
-
-
r
2-oxoisohexanoate + NH3 + NADH + H+
L-leucine + H2O + NAD+
-
26.5% of the activity with 2-oxoisovalerate
-
-
r
2-oxoisohexanoate + NH3 + NADH + H+
L-leucine + H2O + NAD+
-
38.1% of the activity with 2-oxoisovalerate
-
-
r
2-oxoisohexanoate + NH3 + NADH + H+
L-leucine + H2O + NAD+
-
20% of the activity with 2-oxoisovalerate
-
-
r
2-oxoisovalerate + NH3 + NADH + H+
L-valine + H2O + NAD+
-
-
-
-
r
2-oxoisovalerate + NH3 + NADH + H+
L-valine + H2O + NAD+
-
-
-
-
r
2-oxoisovalerate + NH3 + NADH + H+
L-valine + H2O + NAD+
-
-
the 4'-pro-S hydrogen atom of NADH is transferred to the substrate in the reductive-amination reaction
-
r
2-oxovalerate + H2O + NAD+
L-norvaline + NH3 + NADH + H+
-
5.0% of the activity with 2-oxoisovalerate
-
-
r
2-oxovalerate + H2O + NAD+
L-norvaline + NH3 + NADH + H+
-
79.5% of the activity with 2-oxoisovalerate
-
-
r
3-methyl-2-oxopentanoate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
-
68% of the activity with 2-oxoisovalerate
-
-
r
3-methyl-2-oxopentanoate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
-
22.3% of the activity with 2-oxoisovalerate
-
-
r
3-methyl-2-oxopentanoate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
-
24.5% of the activity with 2-oxoisovalerate
-
-
r
3-methyl-2-oxopentanoate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
-
16.6% of the activity with 2-oxoisovalerate
-
-
r
3-methyl-2-oxopentanoate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
-
23.2% of the activity with 2-oxoisovalerate
-
-
r
3-methyl-2-oxopentanoate + NH3 + NADH + H+
L-isoleucine + H2O + NAD+
-
-
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
33% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
16.5% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
125% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
16.5% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
130% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
68.9% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
158% of the activity with L-valine
-
-
r
L-2-aminobutanoate + H2O + NAD+
2-oxobutanoate + NH3 + NADH + H+
-
-
-
-
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
-
16.5% of the activity with L-valine
reductive amination: 48.2% of the activity with 2-oxoisovalerate
r
L-2-aminobutyrate + H2O + NAD+
2-oxobutyrate + NADH + NH3
-
L-2-aminobutyrate is identical with L-alpha-aminobutyrate
reductive amination: 48.2% of the activity with 2-oxoisovalerate
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
1.9% of the activity with L-valine
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
4.5% of the activity with L-valine
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
3% of the activity with L-valine
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
14.7% of the activity with L-valine
-
-
r
L-alanine + H2O + NAD+
pyruvate + NH3 + NADH + H+
-
8.3% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
72% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
46.5% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
34% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
28% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
29.4% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
22% of the activity with L-valine
-
-
r
L-isoleucine + H2O + NAD+
3-methyl-2-oxopentanoate + NH3 + NADH + H+
-
-
-
-
r
L-leucine + H2O + NAD+
2-oxoisohexanoate + NH3 + NADH + H+
-
73% of the activity with L-valine
-
-
r
L-leucine + H2O + NAD+
2-oxoisohexanoate + NH3 + NADH + H+
-
36% of the activity with L-valine
-
-
r
L-leucine + H2O + NAD+
2-oxoisohexanoate + NH3 + NADH + H+
-
52.8% of the activity with L-valine
-
-
r
L-leucine + H2O + NAD+
2-oxoisohexanoate + NH3 + NADH + H+
-
8% of the activity with L-valine
-
-
r
L-leucine + H2O + NAD+
2-oxoisohexanoate + NH3 + NADH + H+
-
24.5% of the activity with L-valine
-
-
r
L-leucine + H2O + NAD+
2-oxoisohexanoate + NH3 + NADH + H+
-
24% of the activity with L-valine
-
-
r
L-norleucine + H2O + NAD+
2-oxohexanoate + NH3 + NADH + H+
-
16% of the activity with L-valine
-
-
r
L-norleucine + H2O + NAD+
2-oxohexanoate + NH3 + NADH + H+
-
10.5% of the activity with L-valine
-
-
r
L-norleucine + H2O + NAD+
2-oxohexanoate + NH3 + NADH + H+
-
18.5% of the activity with L-valine
-
-
r
L-norleucine + H2O + NAD+
2-oxohexanoate + NH3 + NADH + H+
-
51.5% of the activity with L-valine
-
-
r
L-norleucine + H2O + NAD+
2-oxohexanoate + NH3 + NADH + H+
-
34.5% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
43% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH
-
43% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH + H+
-
44% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH + H+
-
100% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH + H+
-
43.0% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH + H+
-
98% of the activity with L-valine
-
-
r
L-norvaline + H2O + NAD+
2-oxovalerate + NH3 + NADH + H+
-
96% of the activity with L-valine
-
-
r
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH + H+
-
-
-
-
r
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH + H+
-
-
-
-
r
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH + H+
-
-
-
-
r
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH + H+
-
-
-
-
r
L-valine + H2O + NAD+
3-methyl-2-oxobutanoate + NH3 + NADH + H+
-
-
-
-
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
NAD+
NADH, 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate, highest activity with 2-oxoisovalerate
r
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
NAD+
NADH, 2-oxoisovalerate is identical with 3-methyl-2-oxobutanoate and alpha-ketoisovalerate, highest activity with 2-oxoisovalerate
r
pyruvate + H2O + NAD+
L-alanine + NH3 + NADH + H+
-
1.3% of the activity with 2-oxoisovalerate
-
-
r
pyruvate + H2O + NAD+
L-alanine + NH3 + NADH + H+
-
20.8% of the activity with 2-oxoisovalerate
-
-
r
pyruvate + H2O + NAD+
L-alanine + NH3 + NADH + H+
-
23.3% of the activity with 2-oxoisovalerate
-
-
r
pyruvate + NH3 + NADH + H+
L-alanine + H2O + NAD+
-
31.6% of the activity with 2-oxoisovalerate
-
-
r
additional information
?
-
-
no substrates: D-valine, glycine, L-threonine, L-serine, L-cysteine, L-glutamate, L-aspartate, L-asparagine, L-arginine, L-histidine, L-tryptophan, and DL-phenylalanine, and 2-ketoglutarate and oxalacetate
-
-
?
additional information
?
-
-
no substrates: D-valine, D-leucine, D-isoleucine, glycine, L-threonine, fialanine, L-serine, L-cysteine, L-methionine, L-glutamic acid, L-aspartic acid, L-asparagine, L-glutamine, L-lysine, L-phenylalanine, L-tyrosine, L-histidine and L-tryptophan as well as 2-oxoglutarate, oxalacetate, phenylpyruvate and glyoxalate
-
-
?
