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1.4.1.26: 2,4-diaminopentanoate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 2,4-diaminopentanoate dehydrogenase (NAD+), go to the full flat file.

Reaction

(2R,4S)-2,4-diaminopentanoate
+
H2O
 +
NAD+
=
(2R)-2-amino-4-oxopentanoate
 +
NH3
 +
NADH
 +
H+

Synonyms

2,4-DAPDH, 2,4-diaminopentanoate dehydrogenase, DAPDH, Fnod_1646

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.26 2,4-diaminopentanoate dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.4.1.26 - 2,4-diaminopentanoate dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R, 4S)-2,4-diaminopentanoate
-
uncompetitive substrate inhibition
-
Ca2+
-
85% residual activity at 0.5 mM
Co2+
-
34% residual activity at 0.5 mM
Cu2+
-
complete inhibition at 0.5 mM
D-alanine
-
enzymatic activity decreases to 71% of the positive control at 5 mM
D-Lysine
-
enzymatic activity decreases to 68% of the positive control at 5 mM
D-ornithine
-
uncompetitive inhibition, enzymatic activity decreases to 14% of the positive control at 5 mM
Fe2+
-
84% residual activity at 0.5 mM
Mg2+
-
65% residual activity at 0.5 mM
Ni2+
-
2% residual activity at 0.5 mM
Zn2+
-
2% residual activity at 0.5 mM
additional information
-
EDTA does not affect the enzyme activity
-