1.4.1.3: glutamate dehydrogenase [NAD(P)+] This is an abbreviated version! For detailed information about glutamate dehydrogenase [NAD(P)+], go to the full flat file .
Reaction
L-glutamate +
H2O +
NAD(P)+ =
2-oxoglutarate +
NH3 +
NAD(P)H +
H+
Synonyms At5g07440, At5g18170, dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)), dual-coenzyme specific glutamate dehydrogenase, GDH, gdh-1, GDH1, GDH2, GDH3, GdhA, gdhA_1, GDHB, GDHII, GLDH, GLUD1, GLUD2, GluDH, glutamate dehydrogenase, glutamate dehydrogenase 1, glutamate dehydrogenase 2, glutamic acid dehydrogenase, glutamic dehydrogenase, hGDH1, hGDH2, hGLUD1, hGLUD2, housekeeping glutamate dehydrogenase, L-glutamate dehydrogenase, L-glutamic acid dehydrogenase, Legdh1, Membrane protein 50, MP50, NAD(P)+-dependent glutamate dehydrogenase, NAD(P)-dependent GDH, NAD(P)-dependent glutamate dehydrogenase, NAD(P)-glutamate dehydrogenase, NAD(P)H-dependent glutamate dehydrogenase, NAD(P)H-utilizing glutamate dehydrogenase, NADH-GDH, NADH-glutamate dehydrogenase, TTC1211, TTC1212, TtGDH
ECTree
Source Tissue
Source Tissue on EC 1.4.1.3 - glutamate dehydrogenase [NAD(P)+]
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dense expression of both isoforms Gdh1 and Gdh2
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gene expression profiling reveals that GLUD2 is selectively and consistently upregulated in glioma cells harboring IDH mutations
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both hGDH1 and hGDH2 are densely expressed in estrogen producing cells
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both hGDH1 and hGDH2 are densely expressed in estrogen producing cells
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predominantly
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high GDH2 expression level
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the enzyme is immunologically distinct from those of other mammalian brains
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expression of both isoforms Gdh1 and Gdh2
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GLUD1 expression analysis
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GLUD1 expression analysis
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upregulation of hGDH1/2 expression occurs in cancer
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high expression in astrocytes, low expression in neurons
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expression of both isoforms Gdh1 and Gdh2
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391541 , 391593 , 391595 , 391596 , 391597 , 391601 , 391602 , 391613 , 391614 , 391616 , 391626 , 391636 , 671289 , 725956 , 742758 brenda
dogfish
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high expression of isoform Gdh1
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from euthermic, 37°C body temperature, and hibernating, 5°C body temperature, animals
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glutamate dehydrogenase 1 is found only in the developing seed
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high GDH2 expression level
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strong expression 0f isoform Gdh2
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mainly in Sertoli cells
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expression of both isoforms Gdh1 and Gdh2
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additional information
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the enzyme occurs in state L3 and adut nematodes
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GDH2 tissue distribution, immunohistochemic analysis using a specific antibody generated with the 12-amino acid hGDH2-specific peptide PTAEFQDSISGA, corresponding to residues 436-447 of the mature human protein, overview
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GDH2 tissue distribution, immunohistochemic analysis using a specific antibody generated with the 12-amino acid hGDH2-specific peptide PTAEFQDSISGA, corresponding to residues 436-447 of the mature human protein, overview
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additional information
no expression in hepaocyte
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no expression in hepaocyte
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no expression in hepaocyte
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no expression in Sertoli cells
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no expression in Sertoli cells
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no expression in Sertoli cells
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neoplastic cell
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neoplastic cell
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neoplastic cell
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