1.4.1.4: glutamate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glutamate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

APE1386, BpNADPGDH I, BpNADPGDH II, dehydrogenase, glutamate (nicotinamide adenine dinucleotide phosphate), EcGDH, GDH, GDH1, Gdh1p, GDH2, GDH3, Gdh3p, GDH4, GdhA, GDHB, GDHC, GDHI, GDHI', GDHII, GDHP, GluDH, glutamate dehydrogenase, glutamate dehydrogenase 1, glutamate dehydrogenase 2, glutamate dehydrogenase 3, glutamic acid dehydrogenase, glutamic dehydrogenase, GW612_14215, H-form specific BpNADPGDH II, hGDH, hyphal-form specific BpNADPGDH II, L-glutamate dehydrogenase, NAD(P)H-dependent glutamate dehydrogenase, NADP(+)-dependent glutamate dehydrogenase, NADP(H)-dependent glutamate dehydrogenase, NADP(H)-GDH, NADP(H)-specific glutamate dehydrogenase, NADP+ - dependant-glutamate dehydrogenase, NADP+-dependent GDH, NADP+-dependent glutamate dehydrogenase, NADP+-Gdh, NADP-dependent GDH, NADP-dependent GluDH, NADP-dependent glutamate dehydrogenase, NADP-dependent glutamate dehydrogenase 1, NADP-dependent glutamate dehydrogenase 2, NADP-GDH, NADP-GDH 1, NADP-GDH 2, NADP-glutamate dehydrogenase, NADP-linked glutamate dehydrogenase, NADP-specific glutamate dehydrogenase, NADP-specific L-glutamate dehydrogenase, NADP-ylGdh1p, NADPH-dependent GDH, NADPH-dependent glutamate dehydrogenase, OsGDH4, Pcal_1606, RocG, TrGDH, Y-form specific BpNADPGDH I, YALI0F17820g, yeast-form specific BpNADPGDH I, ylGDH1

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.4 glutamate dehydrogenase (NADP+)

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Results	in table
49	Activating Compound
1257	AA Sequence
21	Application
1	CAS Registry Number
41	Cloned(Commentary)
229	Cofactor
15	Crystallization (Commentary)
7	Disease/ Diagnostics
15	Expression
61	General Information
22	General Stability
46	IC50 Value
151	Inhibitors
47	kcat/KM [mM/s]
17	Ki Value [mM]
345	KM Value [mM]
13	Localization
13	Metals/Ions
109	Molecular Weight [Da]
129	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
389	Organism
8	Pathway
42	PDB ID
112	pH Optimum
8	pH Range
9	pH Stability
3	pI Value
7	Posttranslational Modification
72	Protein Variants
55	Purification (Commentary)
1	Reaction
5	Reaction Type
235	Reference
49	Source Tissue
74	Specific Activity [micromol/min/mg]
25	Storage Stability
382	Substrates and Products (Substrate)
97	Subunits
247	Synonyms
1	Systematic Name
63	Temperature Optimum [°C]
8	Temperature Range [°C]
88	Temperature Stability [°C]
60	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.4.1.4 - glutamate dehydrogenase (NADP+)

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3,5-pyrazoledicarboxylate

Aspergillus niger

-

activates at lower 2-oxoglutarate concentration

675825

3,5-pyridinedicarboxylate

Aspergillus niger

-

activates at lower 2-oxoglutarate concentration

675825

acetonitrile

Aeropyrum pernix K1

-

activates

391642

ADP

2 entries

AMP

2 entries

ATP

4 entries

CaCl2

2 entries

DL-2-hydroxyglutarate

Aspergillus niger

-

activates at lower 2-oxoglutarate concentration

675825

ethanol

Aeropyrum pernix K1

-

activates up to 40% v/v

391642

GDP

2 entries

Glutarate

Aspergillus niger

-

activates at lower 2-oxoglutarate concentration

675825

GTP

2 entries

IDP

Trichomonas vaginalis

-

at 1 mM five-fold Michaelis Menten constant of 2-oxoglutarate

391669

Itaconate

Aspergillus niger

-

activates even in the presence of 10 mM 2-oxoglutarate

675825

K2HPO4

Archaeoglobus fulgidus

-

at 0.15 M three to fourfold stimulation of activity

391640

K2SO4

Aeropyrum pernix K1

-

280-300% activity at 150-200 mM

391644

K3PO4

Aeropyrum pernix K1

-

less effective than K2SO4 and Na3PO4

391644

KCl

6 entries

methanol

Aeropyrum pernix K1

-

activates

391642

MgCl2

Thermococcus sp.

-

at 5 mM, 104% activity, oxidative deamination

391661

MnCl2

Thermococcus sp.

-

at 5 mM, 250% activity, oxidative deamination

391661

Na2SO4

Aeropyrum pernix K1

-

less effective than K2SO4 and Na3PO4

391644

Na3PO4

Aeropyrum pernix K1

-

280-300% activity at 150-200 mM

391644

NaCl

4 entries

NH4+

2 entries

oxalylglycine

Aspergillus niger

-

activates at lower 2-oxoglutarate concentration

675825

potassium phosphate

Saccharomyces cerevisiae

-

up to 0.1 M oxidative deamination

391684

UTP

Escherichia coli

-

activates up to 70%

391675

Zn2+

Mycolicibacterium smegmatis

-

activates up to 0.1 mM

391679

additional information

Lactococcus lactis

-

exhibits 2.5-fold-higher GDH activity than cells are grown in milk, instead of glucose

671447

-

ADP

Dictyostelium discoideum

-

at 1 mM, 11% activation

391663

ADP

Proteus inconstans

-

at 0.3 mM 40% activation

391680

AMP

Escherichia coli

-

slight activation up to 1 mM

391685

AMP

Salmonella enterica subsp. enterica serovar Typhimurium

-

slight activation up to 1 mM

391689

ATP

Aspergillus terreus

-

30% stimulation in the presence of 2 mM Mg2+

700335

ATP

Escherichia coli

-

at 2 mM, 50% activation

391685

ATP

Proteus inconstans

-

at 0.3 mM, 60% activation of reductive amination

391680

ATP

Salmonella enterica subsp. enterica serovar Typhimurium

-

at 0.8 M, 68% activation

391689

CaCl2

Synechocystis sp.

-

at 20 mM, 25% and 108% activation of reductive amination and oxidative deamination respectively

391673

CaCl2

Thermococcus sp.

-

at 5 mM, 135% activation, oxidative deamination

391661

GDP

Aspergillus terreus

-

30% stimulation in the presence of 2 mM Mg2+

700335

GDP

Trichomonas vaginalis

-

at 1 mM five-fold Michaelis Menten constant of 2-oxoglutarate

391669

GTP

Aspergillus terreus

-

30% stimulation in the presence of 2 mM Mg2+

700335

GTP

Dictyostelium discoideum

-

at 0.083 mM 22% activation

391663

KCl

Aeropyrum pernix K1

-

170-200% activity at 50-100 mM

391644

KCl

Archaeoglobus fulgidus

-

at 0.2 M three to fourfold stimulation of activity

391640, 391648

KCl

Haloferax mediterranei

-

optimal activity at 1-1.5 M

391650

KCl

Pyrococcus furiosus

-

at concentrations below 2 mM

391660

KCl

Pyrococcus woesei

-

at concentrations below 1 mM

391660

KCl

Trypanosoma cruzi

-

up to 50mM

391683

NaCl

Aeropyrum pernix K1

-

170-200% activity at 50-100 mM

391644

NaCl

Archaeoglobus fulgidus

-

at 0.2 M three to fourfold stimulation of activity

391640, 391648

NaCl

Haloferax mediterranei

-

optimal activity at 1-1.5 M

391650

NaCl

Trypanosoma cruzi

-

up to 50 mM

391683

NH4+

Myriophyllum spicatum

-

the activity of glutamate dehydrogenase (GDH) in the ammonium-tolerant species Myriophyllum spicatum leaves performs a dose-response curve (increase of 103% for NADPH-dependent GDH) with the [NH4+-N] increasing from 0 to 100 mg/l while glutamine synthetase (GS) activity slightly changes. Compared to that, for the ammonium-sensitive species, Potamogeton lucens, the activity of GDH records no major changes, while the GS increases slightly (17%)

763741

NH4+

Potamogeton lucens

-

the activity of glutamate dehydrogenase (GDH) in the ammonium-tolerant species Myriophyllum spicatum leaves performs a dose-response curve (increase of 103% for NADPH-dependent GDH) with the [NH4+-N] increasing from 0 to 100 mg/l while glutamine synthetase (GS) activity slightly changes. Compared to that, for the ammonium-sensitive species, Potamogeton lucens, the activity of GDH records no major changes, while the GS increases slightly (17%)

763741