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1.4.1.8: valine dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about valine dehydrogenase (NADP+), go to the full flat file.

Reaction

L-valine
+
H2O
+
NADP+
=
3-methyl-2-oxobutanoate
+
NH3
+
NADPH
+
H+

Synonyms

dehydrogenase, valine (nicotinamide adenine dinucleotide phosphate), ValDH, valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), VDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.8 valine dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.4.1.8 - valine dehydrogenase (NADP+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
2-oxoisovalerate
-
65 mM, 50% loss of specific activity
Ag+
-
0.01 mM in assay buffer
Ca2+
-
1 mM, partial inhibition
diethyldicarbonate
-
20 mM, 60% loss of activity
iodoacetamide
L-valine
Mg2+
-
1 mM, partial inhibition
N-bromosuccinimide
-
0.5 mM, complete inhibition
oxo(phenyl)acetaldehyde
-
5 mM, 60% loss of activity
p-chloromercuribenzoate
p-hydroxymercuribenzoate
pyridoxal 5'-phosphate
-
40% loss of activity, forms Schiff base with a lysine residue
Urea
-
3.5 M, complete and irreversible inactivation
Zn2+
-
1 mM, partial inhibition
additional information
-
no inhibition by nucleotide mono-, di-, triphosphates or the free bases adenine, cytosine, thymine, guanine and uracil
-