1.4.1.8: valine dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about valine dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
dehydrogenase, valine (nicotinamide adenine dinucleotide phosphate), ValDH, valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), VDH
ECTree
1.4.1.8 valine dehydrogenase (NADP+)Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.4.1.8 - valine dehydrogenase (NADP+)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
two forms of enzyme activity: enzyme associated with subcellular structures in shoots or leaves probably plays a biosynthetic role for valine production and the soluble enzyme in roots plays a degradative role in valine catabolism
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first catabolic step of L-valine and some other branched chain L-amino acids, important role in providing precursors for biosynthesis of polyether antibiotic, salinomycin, that is produced at a high level
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
VDH2 rather than VDH1 plays a role in metabolism of branched chain amino acids and thus in tylosin biosynthesis, expression of VDH1 is unstable
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
regulatory enzyme involved in biosynthesis of n-butyrate, a building unit of the oligoketide antibiotic tylosin, NAD+ as natural cofactor for oxidative deamination
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
-
?
L-valine + NAD(P)+ + H2O
2-oxoisovalerate + NH3 + NAD(P)H
-
first step in valine catabolism
-
?
