1.4.3.1: D-aspartate oxidase
This is an abbreviated version!
For detailed information about D-aspartate oxidase, go to the full flat file.
Word Map on EC 1.4.3.1
-
1.4.3.1
-
d-amino
-
n-methyl-d-aspartate
-
nmda
-
d-serine
-
d-glutamate
-
octopus
-
nmdar-dependent
-
d-alanine
-
prepulse
-
humicola
-
d-amino-acid
-
d-ser
-
d-glu
-
drug development
-
molecular biology
-
medicine
- 1.4.3.1
-
d-amino
- n-methyl-d-aspartate
- nmda
- d-serine
- d-glutamate
- octopus
-
nmdar-dependent
- d-alanine
-
prepulse
- humicola
-
d-amino-acid
- d-ser
- d-glu
- drug development
- molecular biology
- medicine
Reaction
Synonyms
aspartic oxidase, C47A10.5 gene product, C47Ap, ChDASPO, ChDDO, D-Asp oxidase, D-aspartic oxidase, D-AspO, DAO, DASOX, DASPO, DDO, DDO-1, DDO-2, DDO-3, DDO1, DDO3, F18E3.7a gene product, F18Ep
ECTree
Advanced search results
General Information
General Information on EC 1.4.3.1 - D-aspartate oxidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
metabolism
physiological function
additional information
-
melatonin secretion and D-Asp release from pinealocytes are enhanced by stimulation with noradrenaline, after which the melatonin secretion is suppressed by the action of the released D-Asp on the cells. Through this negative feedback mechanism, noradrenaline may regulate its ability to induce melatonin secretion in the pineal gland
-
H2O2 is essential for the iodination of the tyrosyl residues to produce mono- and diiodotyrosine that are the precursors for the synthesis of thyroid hormones T3 and T4. interaction of endogenous D-Asp, D-AspO, and D-aspartate racemase in thyroid gland constitutes an additional biochemical pathway for the production of H2O2 and consequently for the synthesis of thyroid hormones, overview
metabolism
-
H2O2 is essential for the iodination of the tyrosyl residues to produce mono- and diiodotyrosine that are the precursors for the synthesis of thyroid hormones T3 and T4. interaction of endogenous D-Asp, D-AspO, and D-aspartate racemase in thyroid gland constitutes an additional biochemical pathway for the production of H2O2 and consequently for the synthesis of thyroid hormones, overview
metabolism
-
in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration, exaggerated D-Asp concentrations activate SOD1 as cytoprotective mechanism in the kidney, whereas, in the brain and in the heart, where the antioxidant action of SOD1 is limited, caspase 3 is activated, overview
metabolism
the reductive half-reaction is reversible. The kinetic mechanism follows a ternary complex mechanism characterized by a very fast step of flavin reduction followed by a rate-limiting reoxidation step
-
D-Asp is important in the development and neurogenesis of the brain. D-Asp plays a regulatory role in the synthesis and secretion of prolactin in the anterior lobe of the pituitary gland. D-Asp directly interacts with DNA and/or acts on nuclear protein(s) involved in the regulation of gene transcription, through which d-Asp controls gene expression in the hypothalamo-neurohypophyseal system
physiological function
-
D-Asp oxidase is a FAD-containing flavoprotein that catalyzes the oxidative deamination of D-amino acids with O2 to generate the corresponding 2-oxo acids, along with H2O2 and NH3. DDO is highly specific for acidic D-amino acids, such as D-Asp, N-methyl-D-Asp, and D-Glu
physiological function
-
D-AspO plays an essential role in decreasing excessive amounts of D-Asp in frog tissues
physiological function
-
in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration. Induction of oxidative stress following D-Asp exposure is primarily related to its metabolism by inducible D-AspO
physiological function
-
relevance of D-Asp and DDO to NMDA receptor-related disease, D-Asp protects against sensorimotor-gating deficits, which are observed in schizophrenic patients, overview. D-Asp is important in the development and neurogenesis of the brain
physiological function
-
relevance of D-Asp and DDO to NMDA receptor-related disease, overview. Phenotype of DDO-deficient mice, DDO-deficient mice display significant deficits in prepulse inhibition, and exhibit reduced immobility time in the Porsolt forced-swim test, a model of depression, suggesting that the genetic ablation of DDO has a specific antidepressant action, overview
physiological function
the D-aspartate oxidase isoforms are involved in egg-laying events and the early development of Caenorhabditis elegans, playing an important role in the development and maturation of germ cells
physiological function
age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging. The enzyme expression is critical to regulate the content of the N-methyl-D-aspartate receptor agonist D-aspartate in adulthood
physiological function
the enzyme plays a role in the modulation of glutamatergic system homeostasis in the mammalian brain
physiological function
the isoform responsible for in vivo metabolism of D-glutamate is DDO3, which is also required for normal self-fertility, hatching, and lifespan
physiological function
-
the D-aspartate oxidase isoforms are involved in egg-laying events and the early development of Caenorhabditis elegans, playing an important role in the development and maturation of germ cells
-