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1.4.3.13: protein-lysine 6-oxidase

This is an abbreviated version!
For detailed information about protein-lysine 6-oxidase, go to the full flat file.

Word Map on EC 1.4.3.13

Reaction

[protein]-L-lysine
+
O2
 +
H2O
=
[protein]-(S)-2-amino-6-oxohexanoate
 +
NH3
 +
H2O2

Synonyms

elastin synthetase, LO, LOR2, LOX, LOX-like 2, LOX-like 3, LOX-like protein, LOX-PP, LOXL, LOXL-2, LOXL1, LOXL1 protein, Loxl2, LOXL2a, Loxl3, LOXL3-sv1, LOXL3a, LOXL3b, LOXL4, LOXL5a, LOXL5b, lysyl oxidase, lysyl oxidase 1, lysyl oxidase 3, lysyl oxidase homolog 2, lysyl oxidase like 4, lysyl oxidase like-1, lysyl oxidase like-1 protein, lysyl oxidase propetide, lysyl oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 2a, lysyl oxidase-like 2b, lysyl oxidase-like 3a, lysyl oxidase-like 3b, lysyl oxidase-like 4, lysyl oxidase-like 5a, lysyl oxidase-like 5b, lysyl oxidase-like protein, lysyl oxidase-like1 protein, lysyl oxidases, More, oxidase-like protein 1, PPLO, protein-6-oxidase, protein-L-lysine:oxygen 6-oxidoreductase, protein-lysine 6-oxidase, RAS excision protein, rDmLOXL-1, WS9-14

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.13 protein-lysine 6-oxidase

Inhibitors

Inhibitors on EC 1.4.3.13 - protein-lysine 6-oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1Z)-butanal thiosemicarbazone
-
-
(2-chloropyridin-4-yl)methanamine
-
-
1-(2-chloropyridin-4-yl)methanamine
-
-
1-(2-fluoropyridin-4-yl)methanamine
-
-
1-(2-methoxypyridin-4-yl)methanamine
-
-
1-(2-phenoxypyridin-4-yl)methanamine
-
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
1-(3-fluoropyridin-4-yl)methanamine
-
-
1-(4-fluorophenyl)methanamine
-
-
1-(4-methoxyphenyl)methanamine
-
-
1-(4-nitrophenyl)methanamine
-
-
1-(pyridin-4-yl)methanamine
-
-
1-(quinolin-4-yl)methanamine
-
-
1-([2,3'-bipyridin]-4-yl)methanamine
-
-
1-phenylmethanamine
-
-
1-[2-(1H-imidazol-1-yl)pyridin-4-yl]methanamine
-
-
1-[2-(trifluoromethyl)pyridin-4-yl]methanamine
-
-
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
1-[3-(hydrazinylmethyl)phenyl]methanamine
-
-
1-[4-(1,3-thiazol-2-yl)phenyl]methanamine
-
-
1-[4-(hydrazinylmethyl)phenyl]methanamine
-
-
1-[5-(trifluoromethyl)[2,3'-bipyridin]-4-yl]methanamine
-
-
2-(pyridin-4-yl)ethan-1-amine
-
-
2-Aminopropionitrile
i.e. BAPN, is an irreversible inhibitor of LOX, involved in regulating the metastatic colonization potential of the human breast cancer cell line MDAMB-231
2-mercaptoethanol
-
weakly inhibitory
2-mercaptopyridine-N-oxide
2-phenylcyclopropan-1-amine
-
-
2-phenylethan-1-amine
-
-
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
3,4-dihydroxybenzoate
-
-
3-aminopropanenitrile
3-aminopropionitrile
-
-
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
4-(aminomethyl)aniline
-
-
4-(aminomethyl)benzonitrile
-
-
4-deoxypyridoxine
-
pyridoxal analogue, 50% inhibition at 3 mM
alpha2-Macroglobulin
-
-
-
ascorbic acid
-
inhibits the purified enzyme in vitro, and the formation of cross-linked collagen
basic fibroblast growth factor
-
reduces enzyme expression in osteogenic cells
-
beta-aminopropionitrile
cyclohexanone thiosemicarbazone
-
-
cycloheximide
cyclopentanone thiosemicarbazone
-
-
diethyldithiocarbamate
-
-
Disulfiram
-
a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview
dithiothreitol
-
-
erythorbic acid
-
stereoisomer of ascorbic acid
glutathione
-
slight inhibition
heparin
-
-
homocysteine
homocysteine thiolactone
hydroxylamine
-
-
Isonicotinic acid hydrazide
low-density lipoprotein
-
methyl 3-(aminomethyl)benzoate
-
-
methyl 4-(aminomethyl)benzoate
-
-
N-[2-([2-[(1-oxidopyridin-2-yl)sulfanyl]ethyl]amino)ethyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
-
fully effective at 0.02 mM
phenylhydrazine
Semicarbazide
taurine
-
-
tert-butyl [2-[(1-oxidopyridin-2-yl)sulfanyl]ethyl]carbamate
-
fully effective at 0.002 mM
thiram
-
a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview
TNFalpha
-
tumor necrosis factor-alpha
-
VE-statin/egfl7 protein
-
interacts with the catalytic domain of lysyl oxidase thereby preventing the crosslink of tropoelastin molecules into mature elastin polymers and regulating vascular elastogenesis
-
vitamin B3
-
-
Zn2+
-
slightly inhibitory
additional information
-