1.4.3.13: protein-lysine 6-oxidase
This is an abbreviated version!
For detailed information about protein-lysine 6-oxidase, go to the full flat file.
Word Map on EC 1.4.3.13
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1.4.3.13
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collagen
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fibrosis
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metastasis
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fiber
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copper
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crosslinking
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amine
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elastic
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glaucoma
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aortic
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stiff
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beta-aminopropionitrile
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tropoelastin
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copper-dependent
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fibril
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metalloproteinases
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procollagens
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biomechanical
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propeptide
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exfoliation
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fibrillar
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tensile
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myofibroblasts
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aneurysm
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pseudoexfoliation
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cutis
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copper-binding
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fibrillin-1
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open-angle
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menkes
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copper-deficient
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prolapse
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fibrillogenesis
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cross-linkage
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desmosine
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copper-containing
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medicine
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benzylamine
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diagnostics
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pentosidine
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synthesis
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microfibrillar
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microfibrils
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elastosis
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ehlers-danlos
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elastolytic
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col3a1
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semicarbazide-sensitive
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cuproenzymes
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c-proteinase
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fibulins
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hydroxylysine
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pyridinoline
- 1.4.3.13
- collagen
- fibrosis
- metastasis
- fiber
- copper
-
crosslinking
- amine
-
elastic
- glaucoma
- aortic
-
stiff
- beta-aminopropionitrile
- tropoelastin
-
copper-dependent
-
fibril
- metalloproteinases
- procollagens
-
biomechanical
- propeptide
-
exfoliation
-
fibrillar
-
tensile
- myofibroblasts
- aneurysm
-
pseudoexfoliation
- cutis
-
copper-binding
- fibrillin-1
-
open-angle
- menkes
-
copper-deficient
-
prolapse
-
fibrillogenesis
-
cross-linkage
- desmosine
-
copper-containing
- medicine
- benzylamine
- diagnostics
-
pentosidine
- synthesis
-
microfibrillar
-
microfibrils
-
elastosis
- ehlers-danlos
-
elastolytic
-
col3a1
-
semicarbazide-sensitive
-
cuproenzymes
-
c-proteinase
-
fibulins
- hydroxylysine
-
pyridinoline
Reaction
Synonyms
elastin synthetase, LO, LOR2, LOX, LOX-like 2, LOX-like 3, LOX-like protein, LOX-PP, LOXL, LOXL-2, LOXL1, LOXL1 protein, Loxl2, LOXL2a, Loxl3, LOXL3-sv1, LOXL3a, LOXL3b, LOXL4, LOXL5a, LOXL5b, lysyl oxidase, lysyl oxidase 1, lysyl oxidase 3, lysyl oxidase homolog 2, lysyl oxidase like 4, lysyl oxidase like-1, lysyl oxidase like-1 protein, lysyl oxidase propetide, lysyl oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 2a, lysyl oxidase-like 2b, lysyl oxidase-like 3a, lysyl oxidase-like 3b, lysyl oxidase-like 4, lysyl oxidase-like 5a, lysyl oxidase-like 5b, lysyl oxidase-like protein, lysyl oxidase-like1 protein, lysyl oxidases, More, oxidase-like protein 1, PPLO, protein-6-oxidase, protein-L-lysine:oxygen 6-oxidoreductase, protein-lysine 6-oxidase, RAS excision protein, rDmLOXL-1, WS9-14
ECTree
1.4.3.13 protein-lysine 6-oxidaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.4.3.13 - protein-lysine 6-oxidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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LOX is highly expressed in early gestational amnion tissue (12-14 weeks)
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LOX on the surface of pyramidal cells in the grey matter, LOXL in the nuclei of cortex cells and in the cytosol of capillary endothelial cells
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of lung: LOX and LOXL, renal tubules: only LOXL, intestinal: only LOXL
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in MCF-10A normal breast epithelial cells stably expressing lysyl oxidase LOX has no effect on cell proliferation. Coexpression of lysyl oxidase and placental lactogen leads to a 121% increase in cell proliferation
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LOX gene expression is reduced in pancreatic cancer cells
apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC-12 cells
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pepsin-secreting, in the basal part of the stomach, only LOX, no LOXL
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determination of LOX activity and expression in donor ocular tissues
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determination of LOX activity and expression in donor ocular tissues
additional information
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different spatial and temporal expression of LOX and LOXL1 during growth and aging, expression analysis of LOXL1 and LOX in the aorta during the development, growth, and aging of LOU rats, overview
subluminal stroma surrounding the implanting blastocyst on day 5 of pregnancy
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subluminal stroma surrounding the implanting blastocyst on day 5 of pregnancy
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localization of LOX and LOXL in different tissue areas, LOXL is found in the apical surface of columnar absorbing cells, LOX is located in the submucosa
from days 6 to 8 of pregnancy, the signals for Lox mRNA and protein are strongly detected in the decidual cells
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from days 6 to 8 of pregnancy, the signals for Lox mRNA and protein are strongly detected in the decidual cells
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lysyl oxidase protein expression is very scarce in normal hearts, it is highly expressed in failing hearts
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overexpressed in head and neck squamous cell carcinoma compared to normal squamous epithelium
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co-localization of LOX and LOXL in alveoli and the epithelia of bronchus and bronchiole
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osteoblastic cell, CRL-2593, expression of LOXL1, 3, and 4, not 2, expression patterns during cell differentiatin and matrix mineralization, 4 weeks, overview
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expression of isozymes during osteoblast differentiation is highly regulated due to their distinct roles in collagen matrix stabilization and subsequent mineralization
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localization of LOX and LOXL in different tissue areas, LOX is located in the inner surface of the pigmented epithelia in the photoreceptor layer, LOXL is located in the inner nuclear layer within the outer plexiform layer and in the ganglion cells
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extract obtained from dill stimulates the LOXL gene expression in dermal equivalents. The stimulation by the dill extract is correlated with increased elastin detection, suggesting an increase in elastogenesis efficiency
additional information
adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, no expression of LOXL-2 in larvae, pupae, and embryos, overview
additional information
adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, no expression of LOXL-2 in larvae, pupae, and embryos, overview
additional information
adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, overview
additional information
adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, overview
additional information
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lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization, expression patterns, LOX and LOXL are expressed in most tissues
additional information
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lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization
additional information
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nearly no enzyme content in blood vessels, expression level of LOX and LOXL in different tissues during development from embryonic, newborn, and young to adult mice, overview
additional information
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high aortic LOX expression early in the development, i.e. embryonic day 15, followed by a drastic reduction in adulthood, whereas LOXL1 is mainly detectable in the intima and media and is expressed throughout life in the LOU rat
additional information
quantitative expression analysis of LOX isozymes in different subcellular compartments in PC-12 cells, overview
