1.4.3.15: D-glutamate(D-aspartate) oxidase
This is an abbreviated version!
For detailed information about D-glutamate(D-aspartate) oxidase, go to the full flat file.
Reaction
Synonyms
ChDASPO, D-aspartate oxidase, D-glutamic-aspartic oxidase, D-monoaminodicarboxylic acid oxidase, DDO, DDO-1
ECTree
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Substrates Products
Substrates Products on EC 1.4.3.15 - D-glutamate(D-aspartate) oxidase
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REACTION DIAGRAM
D-glutamate + H2O + O2
2-oxoglutarate + NH3 + H2O2
the enzyme (DDO-1) efficiently and selectively degrades D-glutamate in addition to D-aspartate, even in the presence of various other amino acids
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additional information
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DL-alpha-aminoadipic acid not deaminated, alpha-aminomalonic acid not deaminated, possible acceptors: oxygen, ferricyanide, 2,6-dichlorophenol-indophenol and methylene blue
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D-aspartic acid + H2O + O2
oxaloacetate + NH3 + H2O2
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D-glutamate and D-aspartate are oxidized at the same rate
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D-aspartic acid + H2O + O2
oxaloacetate + NH3 + H2O2
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DASPO plays an essential role in the assimilation of D-aspartate and acts as a detoxifying agent for D-aspartate
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D-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
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D-glutamate and D-aspartate are oxidized at the same rate
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D-glutamic acid + H2O + O2
2-oxoglutarate + NH3 + H2O2
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enzyme is also involved in the detoxification of D-glutamate, although enzyme induction by this amino acid is very limited
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